Cardiovascular, Psychological Stress
Conditions
Keywords
Spice, responses to stress, Inflammatory
Brief summary
The purpose of this study is to assess whether feeding highly antioxidant spices of providing these same antioxidants as capsules is able to affect cardiovascular risk measures. Because this is a new area of research, the investigators will use many measures to assess this question including blood markers, tests of blood vessel health, measures of blood pressure responses, measures of clotting activity, and other inflammation measures.
Interventions
DIETARY_SUPPLEMENTHigh Antioxidant Spice Blend
14.5 g spice blend incorporated into a delivery meal including: cloves, cinnamon, oregano, rosemary, ginger, black pepper, paprika, garlic powder, and turmeric.
BEHAVIORALTrier Psychological Stressor
This is a psychological stressor that is used to invoked stress responses in human subjects. Subjects are told they are taped and evaluated and deliver the speech in front of a trained panel of judges.
OTHERPlacebo antioxidant concentrate
Placebo capsules
Sponsors
McCormick Science Institute
Penn State University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
30 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 30-65 * BMI 25-40 * Non tobacco user * Resting BP \< 160/100 * Fasting Glucose \< 126 mg/dL
Exclusion criteria
* Tobacco use * Use of female hormones * Breastfeeding or planning to become pregnant during the study * Use of lipid-lowering or blood pressure medications * Chronic Inflammatory Disease or osteoarthritis requiring regular use of medication * Chronic use of any form of anti-inflammatory or anti-psychotic drugs * Use of daily aspirin or supplements (except stable dose of calcium) * History of heart attack or stroke, renal or hepatic disease, implanted medical devices, gastrointestinal disease * Allergy or intolerance to any study foods * Injury to fingers or arms that would interfere with vascular and blood pressure measurements * Inability to comply with study protocol * Allergy to adhesives or latex * Aerobic exercise exceeding 2 hours per week
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IL-6 response to psychological stress at time points equal to and greater than 90 minutes post task | At baseline and intervals up to 2 hours following the stressor and 3.5 hours following the meal |
Secondary
| Measure | Time frame |
|---|---|
| Serum/plasma changes in antioxidant activity and their relationship to inflammation outcomes | At baseline and intervals up to 2 hours following the stressor and 3.5 hours following the meal |
| Endothelial function measured by endopat | At baseline and 3.5 hours following the meal |
| Platelet function measured by PFA-100 | At baseline and specified intervals up to 2 hours following the stressor and 3.5 hours following the meal |
Countries
United States
Outcome results
None listed