Luteal Supplementation With Rec-LH After GnRH-agonist Triggering in In Vitro (IVF)

A Phase IV Study on the Effect of Luteal Supplementation With Rec-LH on the Pregnancy Rate After Ovulation Triggering With GnRH-agonist Instead of HCG in IVF Protocol;Proof of Concept

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00954811

Enrollment

Registered

2009-08-07

Start date

2005-09-30

Completion date

2010-12-31

Last updated

2010-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy, Pregnancy Loss

Keywords

pregnancy

Brief summary

Our aim is to access whether we can achieve equivalent pregnancy rates by the addition of six doses of luteal support with recLH after agonist triggering for IVF cycles in the absence of OHSS.

Detailed description

Whether pregnancy outcome after GnRH-agonist triggering could be improved by adding luteal recLH support plus progesterone, compared to that observed after ovulation triggering with HCG in GnRH antagonist stimulated cycles.

Interventions

DRUG300IU rec-LH

luteal alternate doses

DRUGprogesterone 600mg

luteal support

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 36 Years

Healthy volunteers

Inclusion criteria

* \< 36years, * single blastocystET, * FSH \< 12

Exclusion criteria

* endometriosis, * 3 and 4, * pco, * frozen sperm

Design outcomes

Primary

Measure	Time frame
pregnancy occurrence, pregnancy loss	14 days after OPU

Secondary

Measure	Time frame
hormone levels, OHSS, endometrium	14 days after oocyte pick up

Countries

Belgium

Contacts

Primary ContactEvangelos Papanikolaou, PhD

drvagpapanikolaou@yahoo.gr

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026