Etiology, Epidemiology and Prognostics of Acute Kidney Injury (AKI)

The Study of Etiology, Epidemiology and Prognostic Factors of Acute Kidney Injury

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00953992

Enrollment

651

Registered

2009-08-06

Start date

2009-04-30

Completion date

2019-05-31

Last updated

2019-08-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nutrition Disorders, Renal Failure

Keywords

acute kidney disease, prognosis, oxidative stress, inflammation, gene polymorphism

Brief summary

* To investigate the etiology, epidemiology and prognostic factors of acute kidney injury. * To find out risk factors that relate with the prognosis of acute kidney injury,focusing on inflammation, oxidative stress and nutritional status. * To study on the relationship between gene polymorphism and prognosis of acute kidney injury.

Detailed description

1. to investigate the relationship between preexisting malnutrition and adverse outcomes in patients with AKI \- Several nutritional assessment methods such as anthropometric, clinical and biochemical evaluations have been used; however, no single indicator is considered to be a gold standard. 2. to evaluate the association of serum nutritional variables and prognosis of acute kidney injury 3. Given the different half-lives of serum nutritional markers, we hypothesized that the utility of serum nutritional variables as prognostic predictors may differ in early death (\<7 days) and late death (\>7 days, \<28 days) patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

16 Years to 88 Years

Healthy volunteers

Inclusion criteria

* age \>=16 years and \<= 88 years * clinically diagnosed with acute kidney injury, according RIFLE or KDIGO criteria.

Exclusion criteria

* acute Renal Failure occurring in the setting of burns, obstructive uropathy, allergic interstitial nephritis, acute or rapidly progressive glomerulonephritis, vasculitis, hemolytic-uremic syndrome, thrombotic thrombocytopenic purpura (TTP), malignant hypertension, scleroderma renal crisis, atheroembolism, functional or surgical nephrectomy, hepatorenal syndrome, cyclosporin or tacrolimus nephrotoxicity * Do Not Resuscitate (DNR) status * subjects enrolled in another clinical trial that could affect the outcome of this study protocol

Design outcomes

Primary

Measure	Time frame
renal function survival rate days in the hospital days in the ICU	discharg from hospital, 28days,90days

Countries

China

Outcome results