Ischemic Heart Disease
Conditions
Keywords
remote ischemic preconditioning, cognitive function, off-pump coronary artery bypass graft
Brief summary
The aim of this study is to evaluate the effects of remote ischemic preconditioning on cognitive function in patients undergoing off-pump coronary artery bypass graft.
Interventions
PROCEDUREremote ischemic preconditioning
Remote ischemic preconditioning will be induced by four 5-min cycles of upper limb ischemia and 5-min reperfusion with a blood-pressure cuff inflated to 200 mmHg and be performed before and after the coronary anastomosis
Sponsors
Asan Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing elective off-pump coronary artery bypass graft surgery
Exclusion criteria
* Emergency operation * Preoperative use of inotropic drugs or mechanical assistant device * Ejection fraction less than 30% * Combined operation using CPB such as valve surgery * Previous psychiatric and neurologic disorder * Inability to perform the cognitive function test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cognitive function | preoperative, 1 week and 6 months after surgery |
Countries
South Korea
Contacts
Primary ContactIn-Cheol Choi, professor
Backup ContactDae-Kee Choi, fellow
Outcome results
None listed