Antibiotics in Chronic Obstructive Pulmonary Disease (COPD)

Antibiotic Treatment of Patients Admitted to Hospital With Acute Exacerbation of COPD. Effect of 1 Day of Antibiotic Therapy Compared to 6 Days of Therapy in Patients Who Are Stable After 24 Hours

Status

Withdrawn

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00952861

Acronym

TAExaCOP

Enrollment

140

Registered

2009-08-06

Start date

2009-10-31

Completion date

2010-12-31

Last updated

2010-08-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Keywords

Chronic obstructive pulmonary disease, Infection, Antibiotics

Brief summary

It is not clear whether antibiotic therapy is needed in patients with mild to moderate exacerbation of chronic obstructive lung disease. The aim of the study is to compare the effect of 1 day of treatment with 6 days of treatment in patients who are admitted to hospital and being clinical stable (as judged by their physician) 24 hours after hospitalization

Interventions

DRUGDoxycycline

200 mg QD in 5 days

DRUGPlacebo (matching)

Placebo QD i 5 days

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age above 50 years * History of smoking * History of COPD * Antibiotics for 24 hours * At least 2 of the following: dyspnoea, coughing with sputum, and sputum with purulence * Informed consent

Exclusion criteria

* Pneumonia * Antibiotics for more than 36 hours * Antibiotics for other infection * Prednisolone, more than 0.5 mg/kg body weight/24 hours for more than 3 days * Malignancy * Other pulmonary disease * Immune deficiency * Not able to tolerate doxycycline * Severe heart, liver or kidney disease * Epilepsia * Not stable 24 hours after hospital admission * Need for assisted ventilation

Design outcomes

Primary

Measure	Time frame
6 minutes walking distance	Day 14

Secondary

Measure	Time frame
Time to next episode of acute exacerbation	Days 14, 30, 90 and 180

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026