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Evaluation of the Quality of Cardio-Pulmonary Resuscitation (CPR) in Cardiac Arrest Patients

Evaluating the Quality of Prehospital and In-hospital Cardio-pulmonary Resuscitation - Comparing the Compressions to Concurrent Vital Signs (Invasive Blood Pressure, Cerebral Oxygen Saturation, EtCO2) and Iatrogenic Injuries Associated to Chest Compressions.

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT00951704
Enrollment
1000
Registered
2009-08-04
Start date
2008-11-30
Completion date
2018-12-31
Last updated
2018-12-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Arrest

Keywords

CPR, Tissue Perfusion, invasive arterial pressure, exhaled carbon dioxide, Quality of life, Quality of chest compressions, Epidemiology of sudden cardiac arrest(OHCA)

Brief summary

The prognosis of cardiac arrest patients is generally poor. Recent studies have showed that the high quality of CPR increases the survival after cardiac arrest. Therefore the investigators planned this prospective observational study to determine the epidemiology of sudden cardiac arrest in the prehospital setting of Tampere area, the quality of the CPR, and also the associations between depth and frequency of chest compressions and invasive arterial pressure, EtCO2,cerebral oxygenation and iatrogenic injuries associated to chest compressions 1) in patients resuscitated out of hospital by emergency medical service's (EMS's) personals and 2) in-hospital by hospital resuscitation team members. In addition, the investigators will analyze the effects of the chosen method of resuscitation on critical vital signs (Etco2 and invasive pressures): closed-chest CPR is compared to open-chest CPR, or mechanical CPR with a device (AutoPulse-CPR, Cardio Pump) compared to manual CPR guided with quality CPR device. The results will give the investigators important insights into the haemodynamics of CPR which may guide future strategies for the management of cardiac arrest. The research group is also interested in CPR related injuries and mattress effect. Quality of life after CA is evaluated among survivals and the cause of death among non-survivors.

Interventions

None listed

Sponsors

Turku University Hospital
CollaboratorOTHER_GOV
Uppsala University
CollaboratorOTHER
Tampere University Hospital
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* cardiac arrest * \> 18 years of age

Exclusion criteria

* \< 18 years of age

Design outcomes

Primary

MeasureTime frameDescription
The success rate of current guidelines (depth and frequency of chest compression, epidemiology)During the resuscitation
Quality of life after CA6 monthsQuality of life after CA is usually fairly good measurement of quality of resuscitation attempt

Secondary

MeasureTime frame
Invasive arterial pressures, cerebral oxygenation (NIRS), EtCO2During the resuscitation
survival of cardiac arresthospital discharge

Other

MeasureTime frame
Change in hemodynamics, Change in cerebral saturation, Change in quality of CPRDuring resuscitation

Countries

Finland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 23, 2026