Schizophrenia
Conditions
Keywords
clozapine, schizophrenia, cognition, t-wave morphology
Brief summary
This study aim to investigate the relationship between serum levels of clozapine and cognitive performance in patients with ICD-10 Schizophrenia and treated with clozapine monotherapy. The hypothesis is that higher serum levels of clozapine are associated with cognitive dysfunctions. Furthermore, ECG changes and the relation to serum level of clozapine are studied. The design is cross-sectional.
Interventions
None listed
Sponsors
University of Aarhus
Study design
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Treated with clozapine for minimum 6 months. * Fixed dosage of clozapine last month before inclusion.
Exclusion criteria
* Substance misuse. * Depression (Calgary Depression score ≥7). * Somatic disease that interfere with cognitive performance. * Treatment with benzodiazepines (half-lives \>15 hours not allowed up 14 days prior inclusion and during study. Half-lives \< 15 hours not allowed 3 days prior cognitive testing). * Electroconvulsive therapy. * Treatment with other antipsychotics. * Withdrawal of informed consent. * Compulsory measures. * Treatment with anticholinergics except for atropine drops administered sublingually. * Changes in use of tobacco last month before inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function measured by CANTAB | once |
Secondary
| Measure | Time frame |
|---|---|
| T-wave morphology | Once |
| Sedation VAS,ACES and SWAI scale | once |
Countries
Denmark
Outcome results
None listed