Dose-response Enteral Citrulline for Normal Healthy Volunteers and Surgery Patients

Clinical Trial of Enteral Citrulline in Volunteers With Surgical Repair of Ventral Hernias

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00950976

Enrollment

Registered

2009-08-03

Start date

2008-03-31

Completion date

2010-08-31

Last updated

2012-04-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nutritional Deficiency

Brief summary

To determine the level of citrulline to produce a given amount of arginine in healthy volunteers and surgical patients. Arginine-related amino acids are expected to increase as a result of increased substrate provided by citrulline.

Interventions

OTHERcitrulline

TID for 5 days

OTHERLemonade

TID for 5 days

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* adults, male & female, non-pregnant * BMI 18.5-29.9

Exclusion criteria

* cancer * HIV positive

Design outcomes

Primary

Measure	Time frame
Plasma amino acid levels	8 hours

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026