Arterial Calcifications in Nocturnal Hemodialysis and Renal Transplantation Versus Conventional Dialysis

Is Progression of Arteriosclerosis in ESRD Patients Inhibited by Nocturnal Hemodialysis or Renal Transplantation?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00950573

Acronym

NOCTX

Enrollment

184

Registered

2009-08-03

Start date

2010-01-31

Completion date

2018-12-12

Last updated

2018-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney Disease

Keywords

cardiovascular disease, endstage renal disease

Brief summary

Objective: 1. To assess whether nocturnal hemodialysis and renal transplantation are associated with less progression of coronary arterial calcification, compared with conventional hemodialysis and peritoneal dialysis; 2. To identify the risk factors for coronary arterial calcification in dialysis and transplant patients, and to assess a possible interaction with treatment modality.

Detailed description

To assess whether nocturnal hemodialysis and renal transplantation are associated with less progression of coronary arterial calcification, compared with conventional hemodialysis and peritoneal dialysis; To identify the risk factors for coronary arterial calcification in dialysis and transplant patients, and to assess a possible interaction with treatment modality.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* ESRD * current age \> 18 and \< 75 yr * ability to understand the study procedures * willingness to provide written informed consent

Exclusion criteria

* life expectancy \< 3 months * claustrophobia * allergy to iodinated contrast * treatment incompliance, i.e. non-adherence to dialysis regimens and drug use * GFR \< 30 ml/min (according to MDRD formula) in renal transplant patients * pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Change in coronary artery calcification score	3 yrs	The coronary artery calcification score is measured in Agatston units or cubic millimeters and ranges from zero to theoretically infite. This coronary artery calcicifcation score is a total score for all coronary arteries. A higher score, and thus a higher increase in coronary artery calcification score, therefore represents a worse outcome.

Countries

Netherlands

Outcome results