A Study of the Effect of Plasmaexchange in Patients With Acute Liver Failure

European Multicenter Plasma Exchange Trial (Empet): A Controlled, Open, Randomised, Multicenter Study In Patients With Acute Liver Failure

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00950508

Enrollment

183

Registered

2009-07-31

Start date

1998-06-30

Completion date

2009-07-31

Last updated

2014-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Liver Failure

Brief summary

The aim of this study is to examine if high-volume plasma exchange has a positive effect on mortality in patients with acute liver failure.

Interventions

PROCEDUREHigh volume plasma exchange

3 high volume plasma exchanges over 3 days

PROCEDUREStandard medical treatment

Standard medical treatment

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with acute liver failure in encephalopathy grade 2-4

Exclusion criteria

* alcoholic hepatitis * primary non function liver graft or graft dysfunction * known chronic liver disease * known malignancies * clinical suspicion of brain death

Design outcomes

Primary

Measure	Time frame
mortality	at day 3, day 7

Countries

Denmark, Finland, United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026