Healthy Volunteers
Conditions
Brief summary
Recent reports showed that the opioid buprenorphine is a very potent sodium channel blocker. Buprenorphine not only exerts a strong antinociception, but also a long lasting antihyperalgesic effect. This antihyperalgesic effect is not observed for other clinically employed opioids but is common for local anaesthetics. The principal aim of the study is to compare the speed of onset and the time of recovery of motor blockage achieved by lidocaine and buprenorphine, respectively. The investigators hypothesize that the blocking capacity of buprenorphine is equal to the one of lidocaine.
Interventions
DRUGbuprenorphine
intradermal injection
Sponsors
University of Zurich
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
1. Male 2. Age: 18 - 65 years 3. Weight: 50-100kg 4. Height: 155-195cm 5. Signed and dated informed consent 6. Sufficient command of German language
Exclusion criteria
1. Contraindications to the class of drugs under study 2. Vulnerable subjects (intellectually or mental impaired) 3. Known hypersensitivity to class of drugs or the investigational product 4. Drug abuse 5. Known peripheral neuropathies 6. Diabetes mellitus 7. Chronic alcohol consumption 8. Congestive heart disease 9. Participants of other studies during study period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The principal aim of the study is to measure the speed of onset and the time of recovery of motor blockage achieved by lidocaine and buprenorphine | 6 hours |
Countries
Switzerland
Outcome results
None listed