Infertility
Conditions
Keywords
corpus luteum rescue, Gonadotropin Releasing Hormone (GnRH agonist), human Chorionic Gonadotropin (hCG), infertility, pregnancy rate
Brief summary
This study was designed to evaluate the ability of gonadotropin releasing hormone (GnRh) agonist to prevent the rise of progesterone during controlled ovarian stimulation for in vitro fertilization (IVF) after the administration of human Chorionic Gonadotropin (hCG) on the first day of menses.
Detailed description
The aim of this study is to evaluate the efficacy of a GnRH agonist in preventing the functional rescue of corpus luteum in women submitted to controlled ovarian stimulation with administration of hCG on the first day of menses and to evaluate its effect on pregnancy rate and ovarian steroidogenesis.
Interventions
DRUGGnRH agonist
3,6mg of goserelin acetate, 250mg of hCG, FSH variable dose according to the number of days required for appropriate ovarian stimulation
DRUGControl
250mg of hCG, Zoladex, FSH variable dose according to the number of days required for appropriate ovarian stimulation
Sponsors
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
21 Years to 38 Years
Healthy volunteers
Yes
Inclusion criteria
* age \>21 and \< 38 years old * polycystic ovarian syndrome * risk for ovarian hyperstimulation syndrome
Exclusion criteria
* recurrent abortion * endometriosis * more than 3 IVF failures * use of oral contraceptive pills in the preceding 3 months * low response to gonadotropins
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of functional rescue of corpus luteum | 6 months |
Secondary
| Measure | Time frame |
|---|---|
| Pregnancy rate | 6 months |
| Levels of serum steroids | 6 months |
| Levels of serum gonadotropins | 6 months |
Countries
Brazil
Contacts
Primary ContactCláudia M Gomes, MD
Backup ContactAndré M Rocha, PhD
Outcome results
None listed