Research Study on the Effects of Smoking on Arteries

The Dose Effect Of Cigarette-Smoking On Indices Of Arterial Function And Oxidative Stress

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00948454

Enrollment

105

Registered

2009-07-29

Start date

2003-01-31

Completion date

2006-06-30

Last updated

2009-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Smoking

Keywords

smoking

Brief summary

The current proposal, will elucidate the role of oxidant stress (OS) on arterial function as measured by flow mediated vasodilation. In addition, the investigators will address the hypothesis, that a pro-oxidant might have different degrees of effects on different biological targets, by performing quantitative assessment of the effects of OS on lipids, proteins and DNA.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Chronic smokers (of between 4 and 20 years duration) and non-smokers will be recruited to the GCRC. Smokers will be allocated to a light group, smoking 4-10 cigarettes per day and a heavy smoking group who smoke 11-20 cigarettes per day. * Non-smokers will be defined as those with a life time consumption of no more than 20 cigarettes, do not live or work in a smoky atmosphere. * All individuals will have a normal history and clinical examination, including a normal EKG, urinalysis and serum chemistry, haemogram and negative urinary pregnancy test.

Exclusion criteria

* previously suffered an acute major cardiovascular event * those with a chronic disease * those taking chronic medication * those with a history of alcoholism or substance abuse * Ex-smokers * Subjects, who have less than or equal to 60% platelet aggregation in response to arachidonic acid

Design outcomes

Primary

Measure	Time frame
To assess the dose-related effects of cigarette smoking on flow mediated arterial function in humans.	Study Day

Secondary

Measure	Time frame
To assess the dose-related effects of cigarette smoking on COX activation.	Twice during study day
To assess the dose-related effects of cigarette smoking on novel indices of lipid peroxidation, protein oxidation and DNA modification by lipid adducts.	Study day

Countries

United States

Outcome results