Hypertension
Conditions
Keywords
Kiwi fruits, Blood pressure, Endothelial function, Antioxidant capacity
Brief summary
The purpose of this study is to determine whether the intake of kiwi fruits will reduce systolic and diastolic blood pressure compared to intake of apples. The investigators hypothesize that the increased intake lutein or other components in the kiwi fruit will enhance nitric oxide bioavailability and lead to vascular relaxation.
Detailed description
An interesting finding in the Oslo Antioxidant Study was that intake of 3 kiwi fruits reduced blood pressure in a clinical significant manner compared to controls. The mechanism for the blood pressure reducing effect of kiwi or the responsible components are not elucidated. However, plasma lutein levels and antioxidant capacity measured by the ferric reducing antioxidant power was increased in the kiwi group. Moreover, gene expression was also altered by the increased intake of kiwi.
Interventions
OTHERKiwi fruits
Daily intake of 3 kiwi fruits for 8 weeks
OTHERApple
Daily intake of 1 apple (equivalent in energy) for 8 weeks
Sponsors
University of Oslo
Oslo University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
35 Years to 69 Years
Healthy volunteers
Yes
Inclusion criteria
* Systolic blood pressure 130-159 mmHg * Diastolic blood pressure 85-99 mmHg * Body mass index \<35 kg/m2
Exclusion criteria
* Systolic blood pressure \>160 mmHg or \<129 mmHg * Diastolic blood pressure \>100 mmHg or \<84 mmHg * Current use or need for blood pressure lowering medication * Symptomatic cardiovascular disease, diabetes, renal dysfunction, psychiatric disorder, pregnancy or lactation, history of obesity surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure | 8 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Endothelial function | 8 weeks |
Countries
Norway
Outcome results
None listed