Infective Endocarditis
Conditions
Brief summary
Prospective study including all the consecutive patients admitted at the Department of Cardiology, Timone Hospital wih a definite diagnosis of IE according to the modified Duke criteria. The period of inclusion will be for 24 months. Eighty patients and age-matched control subject will be included. Primary end point are EE occurring during the antimicrobial treatment and secondary end points will be 6-month mortality, vegetation length and the impact of antimicrobial treatment on inflammation-induced procoagulant changes and endothelial cell activation.
Interventions
OTHERULTRASONOGRAPHY trans-esophageal and trans-thoracic , blood test and clinic test
Sponsors
Assistance Publique Hopitaux De Marseille
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* All the patients presenting certain diagnosis of infectious endocardite according to the criteria of modified Duke
Exclusion criteria
* Age \< 18 years * Pregnancy and feeding * Health not allowing to give the assent * Innate abnormalities of the haemostasis * More than a week before the inclu antibiothérapie adapted begun
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Embolic events occurring during the antimicrobial treatment a | 30 months |
Secondary
| Measure | Time frame |
|---|---|
| Will be 6-month mortality, vegetation length and the impact of antimicrobial treatment on inflammation-induced procoagulant changes and endothelial cell activation. | 30months |
Countries
France
Outcome results
None listed