Autism Spectrum Disorder
Conditions
Keywords
Infants, Risk markers, ERP, Parent child interaction, Promoting First Relations, Social Communication
Brief summary
Early connections has two broad goals: * to identify risk indices for autism spectrum disorder (ASD) in 6 to 24 month old infants who have an older sibling with ASD or infants who have an older neurotypical sibling. * to assess whether it is possible to alter risk processes through early intervention with high-risk infants, thereby reducing social-communication delays or the severity of autism symptoms.
Detailed description
Researchers at the University of Washington want to learn more about the benefits of early monitoring and intervention for younger siblings of children with autism spectrum disorders (ASD). The information gained in this study may improve methods of early detection and intervention for infants who may be at risk for developing autism and lead to better outcome for these young children and their families. Participants include families with a child who has been diagnosed with an autism spectrum disorder or typical development and a younger sibling 12 months old or younger. The study protocol includes: (1) comprehensive infant evaluations at the University of Washington Autism Center at 6-months, 12-months, 18-months and 24-months of age. (2) Developmental screening for the older sibling. (3) Questionnaires and phone interviews for parents. (4) Random assignment to an assessment and monitoring intervention group or a University of Washington intervention group. All families will receive advice regarding appropriate intervention services. Families who are assigned to the UW intervention will take part in a parent delivered intervention.
Interventions
BEHAVIORALAssessment, Monitoring & Intervention
Assessment and monitoring at 6, 12, 18 and 24 months; Parent delivered intervention provided between 6 and 12 months.
Sponsors
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
National Institute of Environmental Health Sciences (NIEHS)
Autism Speaks
Washington State Department of Social and Health Services
Autism Science Foundation
University of Washington
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
5 Months to 12 Months
Healthy volunteers
Yes
Inclusion criteria
* Older sibling with ASD (biologically related to participant) * Participant 12 months of age or younger * Within 1 hour of University of Washington * Interested in participating in Intervention
Exclusion criteria
* Out of study area * Serious parent substance abuse or psychiatric history * Diagnosis of known genetic syndromes or neurological conditions (infant participant or older sibling) * Serious motor impairment (infant participant) * Significant prematurity (infant participant)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Autism Symptoms | 12 months | AOSI |
| Mullen Receptive Language Scale | 12 months | Mullen Receptive Language Scale SS |
| Communication and Symbolic Behavior Scale | 12 months | CSBS Total Composite Score |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Parent Child Interaction | 12 months | NCAST Caregiver Total |
| Parent quality of life | 12 months | Questionnaire on Resources and Stress Total Score |
Countries
United States
Outcome results
None listed