Diabetes Mellitus, Type 1, Hyperlipidemias, Immunosuppression
Conditions
Keywords
Type 1 diabetes, Transplants, Immunosuppression, Hyperlipidemia, Nutrition Therapy
Brief summary
The purpose is to investigate possible mechanisms of increased blood lipid levels following transplantation, and also to see if a comprehensive dietary intervention is effective in reducing blood lipid levels in post-transplant patients.
Detailed description
Post-transplantation patients frequently have an increase in blood lipid levels presumed to be due to immunosuppressive agents, however it is currently unknown the mechanisms by which this occurs. Dietary interventions have frequently been unsuccessful in these patients, which may be due to single-nutrient interventions and lack of support and guidance. This research will use stable isotope methods to estimate cholesterol and fatty acid synthesis to determine if these pathways are affected by immunosuppression in patients before and after islet and liver transplant. In addition, it will be determined if a multi-nutrient dietary intervention will be implemented post-transplant can reduce blood lipid levels in to prevent further polypharmacy these patients.
Interventions
DIETARY_SUPPLEMENTDietary intervention - supplements
Supplement bar & spread formulated with key nutrients (fish oil, phytosterols, almonds, soy protein) shown to help in reducing blood lipid levels
Sponsors
Canadian Institutes of Health Research (CIHR)
University of Alberta
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* on islet or liver transplant list * post-transplant \>3 months * physically able to participate in study and intervention
Exclusion criteria
* \< 18 years of age * family history of premature cardiovascular disease or familial hyperlipidemia (control subjects) * cholestatic diseases (liver transplant patients) * type 2 diabetes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cholesterol and fatty acid synthesis | Pre-transplant, post-transplant (>3 months after transplant, up to 2 years) and post-dietary intervention (1 month after post-transplant measurement) |
Secondary
| Measure | Time frame |
|---|---|
| Blood lipid levels | Pre-transplant, post-transplant (>3 months after transplant, up to 2 years) and post-dietary intervention (1 month after post-transplant measurement) |
Countries
Canada
Outcome results
None listed