C Reactive Protein, Erectile Dysfunction, Vascular Disease Detected
Conditions
Keywords
simvastatin, endothelial dysfunction, erectile dysfunction
Brief summary
This is a randomized clinical trial, double-blind, placebo controlled, to verify if simvastatin can improve erectile dysfunction in men with endothelial dysfunction, without any cardiac disease.It is hypothesized that the simvastatin can improve the endothelial function, improving the nitric oxide liberation in corpora cavernosa of the penis, resulting in improvement of erection.
Interventions
DRUGSimvastatin
simvastatin 20 daily for six months.
DRUGPlacebo
Sponsors
Santa Casa de Porto Alegre
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
MALE
Age
35 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Erectile dysfunction * Elevated C reactive protein * Able to adhere the protocol
Exclusion criteria
* Diabetes mellitus * Cardiac disease * Cerebral vascular disease * Hypogonadism * Any contraindication to simvastatin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Penile erection | — |
Outcome results
None listed