Ozone Therapy in Endodontic Practice, in Vivo Study

Phase 4 - Ozone Therapy in Endodontic Practice, in Vivo Study

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00946634

Enrollment

Registered

2009-07-27

Start date

2009-01-31

Completion date

2011-03-31

Last updated

2011-10-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary Apical Periodontite

Brief summary

The ozone therapy has been coming up as a new therapeutic modality. Medicine has been practicing since XIX century and counted great results. It is indicated for the treatment of 260 different pathologies. The researches in Dentistry has showed promising results, indicating a wide spread action in whole dental specialties. The great oxidative power of ozone provides a great antimicrobial effect and it increases the adenosine triphosphate (ATP) synthesis that can be considered as a general improvement of the cell metabolism, which can potentize the repair process. Thus, these facts justify the present study which will assess the increase of speed of apical periodontite repair.

Interventions

DRUGOzone

Regular endodontic protocol preconized by University of Sao Paulo. Root canal irrigation with 1% Sodium Hypochlorite associated to Endo PTC (10mL), final irrigation with EDTA-T 17% remaining for 3 minutes. After a last foaming with ozone gas (Philozon, Santa Catarina, Brazil) at 40mg/L concentration.

DRUGControl (no last irrigation)

DRUGAqueous Ozone

Regular endodontic protocol preconized by University of Sao Paulo. Root canal irrigation with 1% Sodium Hypochlorite associated to Endo PTC (10mL), final irrigation with EDTA-T 17% remaining for 3 minutes. A last irrigation with 10mL of ozonated water at 40mg/mL concentration

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

13 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy patients * Radiographic evidence of apical periodontite * No previous root canal treatment

Exclusion criteria

* Unhealthy patients * Regular response to sensibility test * Previous root canal treatment

Design outcomes

Primary

Measure	Time frame
Acceleration in repair by healing of apical periodontite	3 months

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026