Zinc Deficiency
Conditions
Keywords
zinc supplement, prevention, zinc deficiency, plasma zinc concentration
Brief summary
The study aims to compare the effects of two different formulations of zinc supplements on plasma zinc concentrations among young Burkinabe children.
Detailed description
1\) To investigate the effects of short-term zinc supplementation, provided either as a dispersible tablet containing zinc sulfate (ZinCfant, Nutriset Ltd; Malaunay, France) or as a liquid ZnSO4 solution, on changes in serum zinc concentration, compared with a placebo in young Burkinabe children; and 2) to assess the relationship between change in serum zinc concentration and the presence of altered intestinal permeability within each treatment group.
Interventions
DIETARY_SUPPLEMENTLiquid zinc syrup
Liquid zinc syrup containing 5 mg zinc as zinc sulfate
DIETARY_SUPPLEMENTZinc tablet
Dispersible zinc tablet containing 5 mg zinc
DIETARY_SUPPLEMENTLiquid placebo supplement
Liquid placebo supplement containing 0 mg zinc
Sponsors
Université Polytechnique de Bobo-Dioulasso
Helen Keller International
Nutriset
University of California, Davis
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
6 Months to 23 Months
Healthy volunteers
Yes
Inclusion criteria
* currently breast feeding * informed consent of a parent or guardian.
Exclusion criteria
* symptomatic acute or chronic febrile infections * diarrhea within the past week * consuming vitamin or mineral supplements or zinc-fortified infant formulas
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma zinc concentration | 3 weeks |
Countries
Burkina Faso
Outcome results
None listed