Optimal Amount of Zinc to Include in a Lipid-based Nutrient Supplement (LNS)

Conditions

Malnutrition

Keywords

point-of-use fortification, zinc supplement, lipid-based nutrient supplement, zinc deficiency, micronutrient deficiency, anemia

Brief summary

To assess zinc-related biochemical and functional responses among young Burkinabe children with a presumed high risk of zinc deficiency who receive micronutrient products containing different amounts of zinc, provided with or between meals.

Detailed description

Young healthy children will be identified by periodic consensus in the study area. 3200 infants meeting a set of eligibility criteria will be randomly assigned to receive lipid-based nutrient supplements (LNS) with different amounts of zinc and a placebo or zinc supplement from 9 to 18 months of age. The families will receive the respective supplement at weekly intervals and the participants undergo a morbidity evaluation weekly, anthropometric evaluation at 9, 12, 15 and 18 months and laboratory analyses at enrollment and at 18 months of age. Growth outcomes will be analyzed during the two-year follow up at 24, 30, 36 and 42 months of age.

Souheila Abbeddou, Elizabeth Yakes Jimenez, Sonja Y. Hess, Jérôme W. Somé, Jean‐Bosco Ouédraogo et al. (6 authors)

European Journal of Nutrition2022-07-136 citations

10.1007/s00394-022-02936-6

Small-quantity lipid-based nutrient supplements containing different amounts of zinc along with diarrhea and malaria treatment increase iron and vitamin A status and reduce anemia prevalence, but do not affect zinc status in young Burkinabe children: a cluster-randomized trial.

Abbeddou S, Yakes Jimenez E, Somé JW, Ouédraogo JB, Brown KH, Hess SY.

2017-02-0225 citations

10.1186/s12887-016-0765-9

Effect of zinc added to a daily small-quantity lipid-based nutrient supplement on diarrhoea, malaria, fever and respiratory infections in young children in rural Burkina Faso: a cluster-randomised trial

Jérôme W. Somé, Souheila Abbeddou, Elizabeth Yakes Jimenez, Sonja Y. Hess, Zinéwendé Ouédraogo et al. (9 authors)

BMJ Open2015-09-0125 citations

10.1136/bmjopen-2015-007828

Lipid-Based Nutrient Supplements Plus Malaria and Diarrhea Treatment Increase Infant Development Scores in a Cluster-Randomized Trial in Burkina Faso.

Prado EL, Abbeddou S, Yakes Jimenez E, Somé JW, Ouédraogo ZP, Vosti SA, Dewey KG, Brown KH, Hess SY, Ouédraogo JB.

2015-04-0129 citations

10.3945/jn.115.225524

Small-Quantity Lipid-Based Nutrient Supplements, Regardless of Their Zinc Content, Increase Growth and Reduce the Prevalence of Stunting and Wasting in Young Burkinabe Children: A Cluster-Randomized Trial

Sonja Y. Hess, Souheila Abbeddou, Elizabeth Yakes Jimenez, Jérôme W. Somé, Stephen A. Vosti et al. (9 authors)

PLoS ONE2015-03-27139 citations

10.1371/journal.pone.0122242

Interventions

DIETARY_SUPPLEMENTLNS-Zn5

Daily consumption of 20 g LNS containing 5 mg of zinc and daily placebo supplement

DIETARY_SUPPLEMENTLNS-Zn10

Daily consumption of 20 g LNS containing 10 mg of zinc and daily placebo supplement

DIETARY_SUPPLEMENTLNS-Zn0

20 g of LNS containing 0 mg of zinc and a daily placebo supplement

DIETARY_SUPPLEMENTSuppl-Zn5

Daily 5 mg zinc supplement ant consumption of 20 g LNS containing 0 mg of zinc

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

9 Months to 9 Months

Healthy volunteers

Yes

Inclusion criteria

* 9.0 to 9.9 mo of age

Exclusion criteria

* severe anemia * severely malnourished * presence of bipedal oedema * severe illness * congenital abnormalities * chronic medical condition * known HIV infection of mother or infant * history of peanut allergy * history of anaphylaxis or serious allergic reaction to any substance

Design outcomes

Primary

Measure	Time frame
Change in body composition	9 to 18 mo of age
Change in length and length-for-age Z-score	9 to 18 mo of age
Change in weight and weight-for-age Z-score	9 to 18 mo of age
Incidence of diarrhea and laboratory-confirmed malaria infection	9 to 18 mo of age
Change in plasma zinc concentration	9 to 18 mo of age

Secondary

Measure	Time frame
Change in stunting, underweight, and wasting	9 to 18 mo of age
Change in hemoglobin, iron, vitamin A and iodine status	9 to 18 mo of age
Incidence of acute lower respiratory infection (ALRI)	9 to 18 mo of age
Change in head circumference and mid-upper arm circumference	9 to 18 mo of age

Countries

Burkina Faso

Outcome results

None listed