Suspected Early Lyme Neuroborreliosis
Conditions
Keywords
Lyme neuroborreliosis, Lyme borreliosis, erythema migrans, doxycycline treatment, ceftriaxone treatment, outcome, subjective symptoms
Brief summary
The investigators will compare doxycycline and ceftriaxone in treatment of patients with suspected early Lyme neuroborreliosis and normal CSF cell count. The study hypothesis is that the efficacy and adverse effects of both antibiotics are comparable.
Interventions
DRUGdoxycycline
100 mg bid, 14 days
DRUGceftriaxone
2g x 1 iv, 14 days
Sponsors
University Medical Centre Ljubljana
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
15 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age \>15 years * erythema migrans in 4 months period before neurologic symptoms * normal CSF cell count * absence of more defined clinical symptoms or signs for CNS involvement (radicular pain, meningeal signs, peripheral facial palsy).
Exclusion criteria
* pregnancy * lactation * allergy on doxycycline and ceftriaxone * immune deficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective sequelae and post-treatment subjective symptoms in patients treated for suspected early Lyme neuroborreliosis with normal CSF cell count with doxycycline or ceftriaxone for 14 days. | 1 year follow-up |
Countries
Slovenia
Contacts
Primary ContactKatarina Ogrinc, MD PhD
Backup ContactFranc Strle, PhD MD
Outcome results
None listed