Glaucoma, Ocular Hypertension
Conditions
Keywords
Glaucoma, Ocular Hypertension, Lumigan, Ganfort
Brief summary
The purpose of this study is to examine the ocular hypotensive effect of Bimatoprost and the potential additional effect of the Bimatoprost/Timolol fixed combination in eyes with ocular hypertension, primary open angle glaucoma or exfoliation glaucoma.
Interventions
DRUGBimatoprost and Bimatoprost/Timolol fixed combination.
Following an appropriate wash-out period, participants were given a 5-week long treatment with Bimatoprost 0.03% once daily in the evening followed by a further 5-week long treatment with the Bimatoprost 0.03%/Timolol 0.5% fixed combination administered in the evening.
Sponsors
Larissa University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Primary open angle glaucoma * Exfoliation glaucoma * Ocular hypertension
Exclusion criteria
* Younger than 18 years old * Inability to understand and/or follow study requirements * Women of childbearing potential not using reliable birth control, pregnant or lactating women * History of chronic obstructive pulmonary disease, heart failure, 2nd or 3rd AV block * Anticipated modification of treatment for systemic hypertension during the study period * History of ocular herpes, corneal scarring, conventional or laser surgery or macular pathology * History of allergy, poor tolerability or poor response to study medication * Best corrected visual acuity less than 0.4 * Significant visual field defect (MD\<15.0 dB)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean diurnal intraocular pressure | Five weeks on each medication |
Countries
Greece
Outcome results
None listed