Clinical Evaluation of Insect Repellent and Insecticide Treated Nets in Lao PDR

Clinical Evaluation of Insect Repellent and Insecticide Treated Nets Against Malaria, JE & Dengue in Rural Communities in Lao PDR

Status

UNKNOWN

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00938379

Enrollment

5000

Registered

2009-07-13

Start date

2009-07-31

Completion date

2011-06-30

Last updated

2009-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dengue, Japanese Encephalitis, Malaria

Keywords

mosquito, repellent, vector control, malaria

Brief summary

Rural communities involved in agriculture are often at highest risk of insect-borne diseases in Southeast (SE) Asia. Skin-applied insect repellents may prove a useful means of reducing mosquito-borne diseases for those people working outdoors in high risk areas. This trial is evaluating the use of insect repellent (20% diethyltoluamide) to reduce incidence of malaria, Japanese Encephalitis and Dengue. The investigators will recruit up to 1000 households from 100 villages in rural Laos. In each house the investigators shall recruit up to 5 individuals. Half of households will be randomised to repellent, half to a placebo. All individuals will be provided with insecticide treated bed nets for use at night. All household occupants will be followed for 7 months to record malaria cases by Rapid Diagnostic Test every month. Blood spots will be collected at start and end of study to measure Japanese Encephalitis and Dengue. All positive cases will be promptly treated. Outcome will be reduction in number of malaria cases (primary outcome) and Dengue/Japanese Encephalitis (secondary outcomes).

Interventions

DRUG20% deet insect repellent

skin-applied repellent lotion

DRUGplacebo control

Identical base formulation of lotion but without any deet active

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

5 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* working in agriculture * available for monthly follow-up

Exclusion criteria

* allergy to repellent * pregnant / breastfeeding

Design outcomes

Primary

Measure	Time frame
reduction in malaria incidence	monthly over 7 months

Secondary

Measure	Time frame
Reduction in Japanese Encephalitis and / or Dengue infections	After 7 months intervention

Countries

Laos

Contacts

Primary ContactVanessa Chen-Hussey, MSc

vanessa.chen-hussey@lshtm.ac.uk

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 10, 2026