Placebo Effects on Blood Pressure Induced by Expectancy Manipulation

Effects of Placebos and Verbal Suggestions on Blood Pressure - Randomized Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00937196

Enrollment

Registered

2009-07-10

Start date

2006-08-31

Completion date

2007-03-31

Last updated

2013-08-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Pressure

Brief summary

The objective of the present study was to examine the effects of a single placebo intervention on blood pressure and to investigate autonomic and psychological mediating mechanisms.

Interventions

DRUGPlacebo globuli

placebo globuli administered together with verbal suggestions of a hypotensive drug effect

DRUGHistaminum hydrochloricum globuli

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* informed consent

Exclusion criteria

* not meeting inclusion criteria * hypotension or hypertension * treated or untreated hypertension or hypotension * Severe systemic disorders (tumors, tbc, diabetes, asthma etc) * diseases that influence the cardiovascular or gastrointestinal system * intake of drugs affecting blood pressure and/or autonomic nervous system * pregnancy and lactation phase * body mass index \>= 32 * cardiovascular risk factors (diabetes, smoking) * drug or alcohol abuse * insufficient compliance * participation in another trial within the last three months

Design outcomes

Primary

Measure	Time frame
Blood pressure (systolic, diastolic)	minutes 1 to 30 after intervention

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026