Endothelial Function in Patients With Sickle Cell Anemia Before and After Sildenafil

Status

Withdrawn

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00937144

Enrollment

Registered

2009-07-10

Start date

2009-09-30

Completion date

2010-02-28

Last updated

2010-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sickle Cell Anemia

Keywords

endothelial function, endothelial progenitor stem cells

Brief summary

The investigators would like to study the endothelial function in sickle cell patients without pulmonary hypertension in an in vivo method during a steady state condition before and after sildenafil treatment for 1 month, and to study the effects of this nitric oxide donor by measuring the Flow Mediated Dilatation, by measuring endothelial progenitor stem cells colonies, and by measuring the effect of therapy on markers of inflammation (cell adhesion molecules and cytokines).

Interventions

DRUGViagra (Sildenafil)

Viagra treatment to patients with sickle cell anemia.

DRUGplacebo

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

DOUBLE (Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* patients with sickle cell anemia

Exclusion criteria

* patients with sickle cell anemia during acute crisis

Design outcomes

Primary

Measure	Time frame
endothelial function before and after viagra treatment to patients with sickle cell anemia without pulmonary hypertension	January 2009 till January 2011

Countries

Israel

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026