Immobilization, Physical Inactivity
Conditions
Brief summary
In the present study, the effects of 3 weeks of unloading on muscle mass and muscle fiber characteristics will be determined. In addition, the effects of 6 weeks of recovery will be assessed.
Interventions
BEHAVIORALunloading
2 weeks of unloading of a single leg
Sponsors
Maastricht University Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy * BMI \< 30 kg/m2
Exclusion criteria
* Use of medication that may affect haemostasis * Subjects with (recent) musculoskeletal/orthopaedic disorders known to affect the outcome of the study or that compromise their ability to walk with crutches * Subjects with metal implants in their lower limbs * Subjects with known cardiovascular and/or haemostasis disorders * Subjects with known severe hypertension
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| muscle mass, muscle fiber size | 1 week before unloading; immediately (1 day) after unloading and 6 weeks after unloading |
Secondary
| Measure | Time frame |
|---|---|
| muscle strength | 1 week before unloading; immediately (1 day) after unloading and 6 weeks after unloading |
Countries
Netherlands
Outcome results
None listed