Blood Glucose, Body Weight, Insulin, Lipids
Conditions
Keywords
Flaxseed, Weight loss, Heart health, Diabetes
Brief summary
The aim of this study is to compare the effects of flaxseed on atherogenic lipids, plasma inflammatory markers, and insulin sensitivity. We hypothesize that flaxseed omega-3 fatty acids will improve the lipid profile (decrease triglyceride, total and LDL-cholesterol and increase HDL-cholesterol). Flaxseed is the richest dietary source of lignan secoisolariciresinol diglucoside (SDG). Lignans are estrogens found in plant sources that behave similar to endogenous estrogens and have been associated with cardiovascular benefits due to their antioxidant activity. Therefore, we also hypothesize that flax-lignans will cause a significant decrease in LDL oxidation and in inflammatory markers such as C-reactive protein (CRP), interleukin-6 (IL-6), IL-1B, serum fatty acid binding protein 4 (FABP-4), and serum amyloid attached to high density lipoprotein (HDL-SAA).
Interventions
DIETARY_SUPPLEMENTFlaxseed
Flaxseed omega-3 fatty acids and lignans
Sponsors
Flax Canada 2015 Inc.
University of California, Davis
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
40 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Men or postmenopausal women in the 40-65 years age range. Body Mass Index in the range of 25-39
Exclusion criteria
* Women are are premenopausal * Smoking * Diabetes * Cancer * Gout * Untreated thyroid disease * Kidney Disease * Liver Disease * Use of lipid lowering drugs * Use of insulin sensitizing drugs * Use of ACE inhibitors or other blood pressure lowering medications * Use of over the counter or prescription anti-obesity medications * Weight loss of 10% or more within the last 12 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improved lipid profile | six weeks |
Countries
United States
Outcome results
None listed