Obesity, Overweight
Conditions
Keywords
overweight, obesity, male, fertility
Brief summary
Obesity has been found to be a risk factor for female infertility. Studies have indicated that obese men often have poor semen quality and require increased time to make partner pregnant. To date, no studies have investigated the effect of weight reduction on male fertility. The purpose of this study is to investigate the effect of weight reduction in overweight and obese men on their reproductive function.
Interventions
BEHAVIORALweight loss
self-directed weight loss, guided weight loss, weight loss by gastric by-pass surgery
Sponsors
Oslo University Hospital
The Hospital of Vestfold
Tartu University Hospital
Oslo University College
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age \> 18 * BMI \> 27 kg/m2
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| weight, height, % body fat, sperm (volume, concentration, motility, morphology, vitality), sperm DNA integrity, steroid hormones, gonadotropins, blood glucose, HbA1c, mCRP, lipids, adiponectins, fatty acid composition in serum and sperm phospholipids | minimum three months |
Secondary
| Measure | Time frame |
|---|---|
| genetic variations in genes involved in metabolism and reproduction | no time frame |
Countries
Norway
Contacts
Primary ContactTrine B. Haugen, PhD
Backup ContactOliwia Witczak, PhD
Outcome results
None listed