Oesophageal Cancer
Conditions
Keywords
Positron-Emission Tomography, PET Scan, FDG, oesophageal cancer, chemo-Radiation Oncology, SUV
Brief summary
The poor prognosis in the early-stage of oesophageal carcinoma cancer is due to potential worsening of the disease (local relapse, metastasis), to insufficient efficacy and toxicity of actual treatments. FDG-PET is a medical imaging modality allowing the quantification of the tumour glucose consumption. Then, this exam is used for pathology staging, target volume definition for RT, and treatment efficiency few months after CRT. Our assumption is that an FDG-PET exam during the course of CRT might be predictive of the treatment efficiency few months later. In this study, we propose to perform 4 FDG-PET: first PET1 before chemo-radiotherapy, second PET2 during the chemo-radiotherapy (see RTEP1), third and fourth PET3 PET4 3month and 12 month after the end of radiotherapy. We will investigate the performances of FDG-PET performed during CRT for the prediction of the one-year patient heath outcome. If the predictive value of TEP2 is confirmed, we would be able to optimize the planning treatment during the course of the therapy.
Interventions
None listed
Sponsors
Centre Henri Becquerel
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Carcinoma épidermoïde of the oesophagus histologically proved, UICC Stage II B, III or IVa (TNM on 2002) * Decision of treatment by radio concomitant chemotherapy (radiotherapy in classic spreading of 50Gy associated with a platinum chemotherapy.
Exclusion criteria
* Presence of a second evolutionary cancer in the previous three years * index of performance OMS \> 2 * Patients badly balanced diabetics
Countries
France
Contacts
Primary ContactTHILLAYS Marc, RCA
Outcome results
None listed