Dyslipidemia, Inflammation, Obesity
Conditions
Keywords
Camellia sinensis, Ilex paraguariensis, Green tea, Yerba mate tea, Maté, Dyslipidemia, Inflammation, Obesity
Brief summary
The investigators aim to study the effects of green tea and maté consumption on lipid and inflammatory profiles in dyslipidemic and overweight subjects.
Detailed description
Recommendations of lifestyle and dietary content changes are often made for primary prevention and improvement of many health conditions, including cardiovascular disease. For centuries, green tea (Camellia sinensis) has been linked to good health. Nowadays, it is considered a functional food because of its physiological benefits, mainly in terms of cardiovascular prevention. Green tea is considered one of the best sources of phenolic compounds, which possess antioxidant properties that may contribute to a reduction in the risk of cardiovascular disease. Lesser-known worldwide, but widely consumed in southern Latin America countries, yerba mate tea (Ilex paraguariensis) is also a good source of phenolic compounds. The antioxidant capacity of green tea has been extensively studied; however, few studies have reported that the antioxidant properties of maté tea is even greater than green tea. For this reason, the present study aims to compare the possible effects of the oral ingestion of maté and green tea on the lipid and inflammatory profiles in a southern Brazilian population.
Interventions
DIETARY_SUPPLEMENTYerba Mate Tea
Before and after 8 weeks, serum lipids, C-reactive protein and fibrinogen will be measured. They will also be tested for glycemia, insulin, aminotransferases, bilirubin. Anthropometric measurements will be also performed at week 0 and 8. The subjects will receive instructions to maintain their usual dietary intake and normal physical activity.
DIETARY_SUPPLEMENTGreen tea
Before and after 8 weeks, serum lipids, C-reactive protein and fibrinogen will be measured. They will also be tested for glycemia, insulin, aminotransferases, bilirubin. Anthropometric measurements will be also performed at week 0 and 8. The subjects will receive instructions to maintain their usual dietary intake and normal physical activity.
DIETARY_SUPPLEMENTApple tea
Before and after 8 weeks, serum lipids, C-reactive protein and fibrinogen will be measured. They will also be tested for glycemia, insulin, aminotransferases, bilirubin. Anthropometric measurements will be also performed at week 0 and 8. The subjects will receive instructions to maintain their usual dietary intake and normal physical activity.
Sponsors
Instituto de Cardiologia do Rio Grande do Sul
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
35 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* age 35-60 years * non-treated dyslipidemia (TC \> 200mg/dL and/or TG \> 150 mg/dL and/or HDL-c \< 40 mg/dL for men and 50mg /dL for women) * BMI 25-35 Kg/m²
Exclusion criteria
* use or indication for use of lipid-lowering agents and/or vitamin supplement * non-steroids anti inflammatory use * hormone replacement therapy * contraceptive use * pregnancy * nursing * unexplained weight loss (\>2 Kg) 2 months before the study * altered hepatic function * those who do not sign the informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of lipid (total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides and total cholesterol / HDL-cholesterol ratio) and inflammatory profiles (C- reactive protein and fibrinogen). | 8 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Decreases in body weight, body mass index, body fat ratio, abdominal and waist circumferences and waist to hip ratio. Changes in glucose and insulin will also be evaluated. | 8 weeks |
Countries
Brazil
Outcome results
None listed