Head and Neck Cancer
Conditions
Keywords
DCE MRI, PET, Perfusion, Permeability, Cancer of the head and neck, Head, Neck neoplasms
Brief summary
Dynamic contrast-enhanced (DCE) - magnetic resonance imaging (MRI), diffusion-weighted (DW)-MRI, and fludeoxyglucose - positron emission tomography - computed tomography (FDG-PET-CT) are three modalities that generate non-invasive, functional images of tumors and normal tissues based on physiologic properties including perfusion, vascular permeability and glucose metabolism. Demonstrating that these parameters are associated with clinical outcome, either efficacy or toxicity, could enhance the ability to select patients for different treatment strategies and improve the therapeutic ratio.
Detailed description
Patients will undergo functional imaging studies, DCE-MRI pre-treatment (twice) and after 1 week of Radiation Therapy (RT) and PET scans - pre-treatment and after 1 week of RT. Parotid gland saliva production will also be measured at baseline and at 3, 6, and 12 months of follow-up.
Interventions
PROCEDUREMRI and PET imaging
Dynamic Enhanced Magnetic Resonance Imaging (DEC-MRI) and positron emission tomography (PET) scan at baseline and after 1 week of radiation therapy
Sponsors
Duke University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Histologically documented squamous cell carcinoma of the head and neck (AJCC stages II-IV, M0) * Eligible anatomic sites: Oral cavity, oropharynx, hypopharynx, supraglottic and glottic larynx, or nasopharynx * Curative intent concurrent chemoradiation * Age \> 18 years * Karnofsky Performance Status \> 60 * Able to undergo MRI with contrast (gadolinium) and/or FDG PET scan
Exclusion criteria
* Diabetes other than diet controlled * MRI Absolute Contraindications including: * Glomerular filtration rate \< 60 ml/min * Weight \< 350 lb or current device limitations * Metallic foreign bodies in the eye * Cardiac pacemakers * Clips in the central nervous system (ferromagnetic haemostatic) * Automatic internal cardiac defibrillators * Cochlear implants * Shrapnel in vital locations * Pregnant (positive pregnancy test) or lactating
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Permeability, perfusion, diffusion and glucose metabolism | At end of 1 week of radiation therapy |
Secondary
| Measure | Time frame |
|---|---|
| Relationships between baseline and treatment induced changes in vascular permeability, perfusion, interstitial space, glucose metabolism, and saliva production to identify prognostic and predictive parameter(s) for treatment | 1 year of completing radiation therapy |
Countries
United States
Outcome results
None listed