Gingivitis, Halitosis
Conditions
Keywords
Camellia sinensis, volatile sulfur compounds
Brief summary
The purpose of this study is to determine effect of Mouthwash containing Camellia sinensis extracts on oral malodor and gingival inflammation in gingivitis subjects.
Detailed description
At baseline, level of volatile sulfur compounds (VSC) in mouth air, Plaque Index and Papillary Bleeding Index will be recorded. Gingivitis subjects will be asked to rinse with Camellia sinensis mouthwash or placebo mouthwash. VSC level will be measured at 30 minutes and 3 hours post-rinsing. For the following 4 weeks, subjects will be rinsed with the assigned mouthwash twice daily after toothbrushing. All parameter will be recorded again at Day 28.
Interventions
DRUGCamellia sinensis mouthwash
mouthrinsing, 2 times/day, for 28 days
DRUGPlacebo mouthwash
mouthrinsing, 2 times/day, for 28 days
Sponsors
Mahidol University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* at least 20 teeth * clinical diagnosis as plaque induced gingivitis * having over 80 ppb of volatile sulfur compounds in mouth air
Exclusion criteria
* smoker * denture wearer * having systemic diseases or oral pathology * taking antibiotics 1 month prior to study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| level of volatile sulfur compounds in mouth air (part per billion) | baseline, 30 minutes, 3 hours, 28 days |
Secondary
| Measure | Time frame |
|---|---|
| Papillary bleeding index | baseline, 28 days |
Countries
Thailand
Outcome results
None listed