Endothelial Cell Loss After Cataract Surgery

Endothelial Cell Loss After Cataract Surgery: Comparison of a Reduced Ultrasound Technique Versus Standard Ultrasound Technique

Status

Terminated

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00932191

Enrollment

Registered

2009-07-03

Start date

2009-07-31

Completion date

2012-07-31

Last updated

2014-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cataracts

Keywords

Cataract, Corneal endothelial cell loss, Ultrasound power, Corneal endothelium

Brief summary

The purpose of this study is to compare two cataract surgical technique variations for removing the nucleus of the lens (central part of the lens) in terms of damage to the inner layer of the cornea which is called the endothelium. One variation uses more ultrasound energy and the other more mechanical force to break up the nucleus.

Interventions

PROCEDUREStandard phacoemulsification

Cataract nucleus removal using standard amounts of ultrasound energy

PROCEDUREReduced ultrasound phacoemulsification

Cataract nucleus removal using less ultrasound energy and more mechanical energy.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

40 Years to No maximum

Healthy volunteers

Inclusion criteria

* Visually significant moderate density cataract

Exclusion criteria

* Corneal or retinal pathology limiting visual potential to worse than 20/40 * Lens pathology including pseudoexfoliation or lens dislocation * Prior intraocular surgery * Age less than 40

Design outcomes

Primary

Measure	Time frame
Corneal endothelial cell loss by specular microscopy after cataract surgery	3 months post-operatively

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026