Vitamin K-absorption From Dairy

Absorption of Different Forms of Vitamin K From Dairy Products

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00931437

Enrollment

Registered

2009-07-02

Start date

2009-04-30

Completion date

2009-11-30

Last updated

2010-12-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

vitamin K, Bio-availability

Brief summary

Lactic acid bacteria produce a mixture of higher menaquinones, including menaquinone-9 (MK-9) and menaquinone-10 (MK-10). Vitamin K1 (phylloquinone) is normally present in chloroplasts in green vegetables. A new dairy product is developed containing both vitamin K1 and K2-vitamins. However, the extent to which the various forms of vitamin K are absorbed from such a mixture is not known. In this study the absorption profile of phylloquinone and menaquinones from this new dairy product containing several K-vitamins is investigated. This study describes a dietary intervention experiment for one single cocktail containing several K-vitamins as part of a dairy product.

Interventions

DIETARY_SUPPLEMENTvitamin K-rich dairy product

several forms of vitamin K: phylloquinone, menaquinone-7,-8,-9,and -10.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy men and women between 20 and 45 years old * Subjects of normal body weight and height according to BMI \< 30 * Subjects of Caucasian race * Subject has given written consent to take part in the study

Exclusion criteria

* Subjects with (a history of) metabolic or gastrointestinal disease * Subjects presenting chronic degenerative and/or inflammatory disease * Abuse of drugs and/or alcohol * Subjects receiving corticoid treatment * Subjects using oral anticoagulants

Design outcomes

Primary

Measure	Time frame
serum vitamin K levels: phylloquinone, menaquinone-7,-8,-9,and -10	one single intake

Secondary

Measure	Time frame
distribution of vitamin K-forms over lipoprotein fractions: triglyceride rich lipoprotein (TGRLP), intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL), high density lipoprotein (HDL) as well as the lipoprotein-free fraction (LPF)	one single intake

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026