Effects of Dietary Protein on Undesirable Postprandial Events in Overweight Subjects

Conditions

Overweight

Brief summary

Dietary protein differing by their amino acid composition could modulate undesirable metabolic and functional responses to a meal rich in saturated fat and sugars. This study aims at examining the specific effects of dairy protein with different cysteine contents on the postprandial undesirables effects elicited by the ingestion of a high fat meal in overweight subjects.

Pujos-Guillot E, Brandolini-Bunlon M, Fouillet H, Joly C, Martin JF, Huneau JF, Dardevet D, Mariotti F.

2018-06-013 citations

10.1093/jn/nxy049

Casein Compared with Whey Proteins Affects the Organization of Dietary Fat during Digestion and Attenuates the Postprandial Triglyceride Response to a Mixed High-Fat Meal in Healthy, Overweight Men.

Mariotti F, Valette M, Lopez C, Fouillet H, Famelart MH, Mathé V, Airinei G, Benamouzig R, Gaudichon C, Tomé D, Tsikas D, Huneau JF.

2015-10-2123 citations

10.3945/jn.115.216812

Interventions

DIETARY_SUPPLEMENTPostprandial metabolic and functional measures

After ingestion of a high fat meal containing the different protein sources, the subjects undergo a series of measures of endothelial dysfunction and blood and urine sampling for the assessment of proinflammatory cytokines levels and metabolomics determinations.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* BMI between 25 and 30 * Waist circumference \> 94 cm

Exclusion criteria

* Allergy to milk protein * Abusive drug consumption * Smoking * Hypertension, diabetes * High level of physical activity

Design outcomes

Primary

Measure	Time frame
Endothelial dysfunction	0-2-4-6 hours (after meal ingestion)

Secondary

Measure	Time frame
Postprandial inflammation	0-0.5-1-1.5-2-3-4-6 hours (after meal ingestion)

Countries

France

Outcome results

None listed