Migraine Disorders, Obesity
Conditions
Keywords
Migraine, Children, Primary headache disorders, Appetite, Obesity, Feeding Behavior
Brief summary
The purpose of this study is to determine whether there is an association between migraine in children and certain patterns of appetite or eating behaviour that may lead to later obesity.
Detailed description
Migraine is a chronic neurological disorder characterized by recurrent episodes of headache and associated symptoms. The condition affects approximately 11% of the child population and it can impose considerable burdens on the sufferer either due to the headache itself, or associated co-morbidities such as psychological stress, obesity, sleep problems, etc. Increasing attention is focussing on the shared genetic, environmental and neurobiological mechanisms of migraine co-morbidities to gain further insights into improving outcomes. We are interested in studying eating behaviours in children with migraine since there is evidence that altered patterns of eating behaviour (and underlying changes in appetite) are seen in migraineurs although not studied systematically. Altered appetite and eating behaviours may be a mechanism for the emerging association between obesity (or degree of adiposity) and migraine severity, detected in both adult and paediatric studies to varying extents. Studying the putative association between migraine, degree of adiposity and patterns of eating behaviour in children may help to tease out causal mechanisms, since both migraine and obesity often evolve over the course of childhood.
Interventions
None listed
Sponsors
University of Liverpool
Alder Hey Children's NHS Foundation Trust
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
5 Years to 16 Years
Healthy volunteers
No
Inclusion criteria
* Children and adolescents between 5 years and 16 years of age. * Clinical diagnosis of migraine (for cases). * Controls are recruited from children referred with headache, who do not receive diagnosis of migraine.
Exclusion criteria
* Adolescents 17 years or over. * Secondary migraine-like disorder e.g., post-craniotomy headache.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pearson's correlation between PedMIDAS score (measure of migraine severity) and eating behaviour subscale score on the Child Eating Behaviour Questionnaire or Dutch Eating Behaviour Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Regression coefficient of PedMIDAS score or categories of headache frequency on eating behaviour subscale scores, with covariates of Achenbach Child Behavior Checklist score, current BMI, age, sex, length of history of migraine. | — |
| Descriptive analysis of type and severity of typical food cravings and dietary habits using the Food Craving Inventory score and a food intake questionnaire. | — |
Countries
United Kingdom
Outcome results
None listed