Atypical Hemolytic Uraemic Syndrome
Conditions
Brief summary
Atypical hemolytic uraemic syndrome is caused by defects in the regulating factors in the alternative pathway of the complement system. Triggering can cause an uncontrolled complement activation with endothelial damage and thrombotic micro-angiopathy, especially in the kidneys. This can result in endstage renal failure. Complement activation during hemodialysis has been described as a result of contact between blood and the dialysis membrane. Our hypothesis is that patients with atypical hemolytic uraemic syndrome have a stronger complement activation during hemodialysis than patients with another underlying kidney disease. This could be a reason to treat patients with endstage renal failure due to atypical hemolytic uraemic syndrome preferentially with peritoneal dialysis instead of hemodialysis.
Interventions
None listed
Sponsors
University Hospital, Ghent
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* cases: endstage renal failure due to atypical hemolytic uraemic syndrome treated with hemodialysis. * controls: endstage renal failure due to a non complement consuming nephropathy treated with hemodialysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| C3a-des-Arg measuring (as a marker of activation). | at time 0, at 15 minutes, at 60 minutes and at 180 minutes |
| white blood cell count | before and after 15 minutes of hemodialysis |
Countries
Belgium
Outcome results
None listed