Cancer, Sepsis, Septic Shock
Conditions
Keywords
sepsis, septic shock
Brief summary
The mortality induced by infections in onco-hematological patients is abnormally high at the acute phase of septic shock. Consequently, it is important to detect the population with a high risk of short term mortality among patients with a septic shock. The aim of this study is the evaluation of predictive proteic profile on the short term mortality in the acute phase of septic shock in cancer patients.
Detailed description
Method: Monocentric prospective study with diagnostic and prognostic expectations. Primary objective: Identification and characterization of early proteic biomarkers predictive of short term mortality in cancer patients with septic shock. Secondary objective: Research of clinical and biological prognostic factors.
Interventions
OTHERSELDI-TOF MS for plasmatic proteic profile
An extra blood sample is required to determine the plasmatic proteic profile used to identify one or several signatures which are correlated to the clinical evolution (mortality at D30).
Sponsors
Institut Paoli-Calmettes
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient from oncology or hematology with a septic shock * Patient aged 18 years and older * Inclusion within the 24 hours of the septic shock in the intensive care unit * Signed consent according to the emergency reglementation
Exclusion criteria
* Pregnancy, breast feeding * Patient with decision of care limitation * Patient with legal protection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identification and characterization of early proteic biomarkers predictive of short term mortality in cancer patients with septic shock. | 1 month |
Secondary
| Measure | Time frame |
|---|---|
| Research of clinical and biological prognostic factors. | 1 month |
Countries
France
Outcome results
None listed