Peripheral Effects of Endotoxin on Insulin Resistance

The Effect of Regional Inflammation on Metabolism and Insulin Sensitivity in the Lower Extremity.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00929136

Enrollment

Registered

2009-06-26

Start date

2009-06-30

Completion date

2010-05-31

Last updated

2010-10-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Endotoxin, Insulin resistance, Lipolysis, Proteolysis, Intracellular Insulin Signaling, Regional effects of inflammation/endotoxin

Brief summary

The aim of the study is to isolate the direct effects of endotoxin on glucose, lipid and protein metabolism. Eight healthy volunteers are enrolled. The hypothesis is that endotoxin will induce insulin resistance, lypolysis and proteolysis acutely.

Interventions

BIOLOGICALUSP endotoxin

Continuous intra-arterial infusion

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

MALE

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

1. Normal health 2. 22 \< BMI \< 28 3. Written Informed Concent

Exclusion criteria

1. Any disease 2. Any use of medication 3. Recent immobilization of a lower extremity

Design outcomes

Primary

Measure	Time frame
glucose concentration	360 minutes observation

Secondary

Measure	Time frame
Regional arteriovenous amino-acid balance	measured at t=180 and 360 minutes
Intra-cellular insulin signaling	measured at t=0, 120, and, 210 minutes
Regional arteriovenous lipid balance	measured at t=180 and 360 minutes

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026