Skip to content

Mechanisms of Neural Mobilization in the Treatment of Chronic Pain

Mechanisms of Neural Mobilization in the Treatment of Chronic Pain

Status
Completed
Phases
Phase 1Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00929123
Enrollment
40
Registered
2009-06-26
Start date
2007-05-31
Completion date
2009-06-30
Last updated
2015-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carpal Tunnel Syndrome

Keywords

manual therapy, carpal tunnel syndrome, central sensitization

Brief summary

The purpose of this study was to determine the effect of a manual therapy technique (neural mobilization) on measures of clinical pain and function, experimental pain sensitivity, and on the function of the median nerve in individuals with carpal tunnel syndrome. The investigators hypothesized that individuals receiving a neural mobilization technique known to directly stress the median nerve would demonstrate greater improvements in clinical pain and function, experimental pain sensitivity, and median nerve function than those receiving a sham technique.

Interventions

PROCEDUREneural mobilization

manual therapy technique known to directly stress the median nerve

sham technique mimicking the neural mobilization which is not specific to the median nerve

OTHERhealthy controls

People without carpal tunnel syndrome for comparison

Sponsors

National Center for Complementary and Integrative Health (NCCIH)
CollaboratorNIH
University of Florida
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes

Inclusion criteria

* 18 to 70 years of age * signs and symptoms of carpal tunnel syndrome for greater than 12 weeks

Exclusion criteria

* non english speaking * prior surgery for carpal tunnel syndrome * systemic condition known to affect sensation * chronic pain condition other than carpal tunnel syndrome

Design outcomes

Primary

MeasureTime frame
thermal and pressure pain sensitivityimmediate effect

Secondary

MeasureTime frame
grip strength3 weeks
wrist range of motion3 weeks
clinical pain3 weeks
self report of disability3 weeks
median nerve function3 weeks

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026