1-year Study to Assess the Efficacy, Safety, and Tolerability of Glycopyrronium Bromide (NVA237) in Chronic Obstructive Pulmonary Disease (COPD)

A 52-week Treatment, Randomized, Double-blind, Placebo-controlled, With Open-label Tiotropium, Parallel-group Study to Assess the Efficacy, Safety, and Tolerability of Glycopyrronium Bromide (NVA237) in Patients With Chronic Obstructive Pulmonary Disease

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00929110

Acronym

GLOW2

Enrollment

1066

Registered

2009-06-26

Start date

2009-06-30

Completion date

2011-04-30

Last updated

2012-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

COPD, NVA237, glycopyrronium bromide

Brief summary

This study was designed to investigate the 1 year efficacy and safety of the 50 µg once daily (od) dose of glycopyrronium bromide (NVA237) in patients with moderate to severe chronic obstructive pulmonary disease.

Interventions

DRUGGlycopyrronium bromide

Glycopyrronium bromide was supplied in powder-filled capsules together with a single-dose dry-powder inhaler (SDDPI) device.

DRUGPlacebo to glycopyrronium bromide

Placebo to glycopyrronium bromide was supplied in powder-filled capsules together with a single-dose dry-powder inhaler (SDDPI) device.

DRUGTiotropium

Tiotropium was supplied in powder-filled capsules together with the Handihaler® device.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

40 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Male or female adults aged ≥ 40 years, who have signed an Informed Consent Form prior to initiation of any study-related procedure. 2. Patients with moderate to severe stable chronic obstructive pulmonary disease (COPD, Stage II or Stage III) according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) Guidelines 2008. 3. Current or ex-smokers who have a smoking history of at least 10 pack years. 4. Patients with a post-bronchodilator forced expiratory volume in 1 second (FEV1) ≥ 30% and \< 80% of the predicted normal, and post-bronchodilator FEV1/forced vital capacity (FVC) \< 0.7 at Visit 2 (Day -14). 5. Patients, according to daily electronic diary data between Visit 2 (Day -14) and Visit 3 (Day 1), with a total score of 1 or more on at least 4 of the last 7 days prior to Visit 3 (Day 1).

Exclusion criteria

1. Pregnant women or nursing mothers (pregnancy confirmed by positive urine pregnancy test). 2. Women of child-bearing potential, unless using an approved method of medical or surgical contraception. 3. Patients requiring long term oxygen therapy (\> 15 h a day) on a daily basis for chronic hypoxemia, or who have been hospitalized for an exacerbation of their airways disease in the 6 weeks prior to Visit 1 (Day -21) or between Visit 1 (Day -21) and Visit 3 (Day 1). 4. Patients who have had a respiratory tract infection within 6 weeks prior to Visit 1 (Day -21). 5. Patients who, in the judgment of the investigator or the responsible Novartis personnel, have a clinically relevant laboratory abnormality or a clinically significant condition. 6. Patients with any history of asthma indicated by (but not limited to) a blood eosinophil count \> 600/mm\^3 (at Visit 1, Day -21) and onset of symptoms prior to age 40 years. 7. Patients with a history of long QT syndrome or whose QTc measured at Visit 1 (Day -21) (Fridericia method) is prolonged (\> 450 ms for males or \> 470 ms for females. Other protocol-defined inclusion/

Design outcomes

Primary

Measure	Time frame	Description
Trough Forced Expiratory Volume in 1 Second (FEV1) at Week 12	Week 12	FEV1 was measured with spirometry conducted according to internationally accepted standards. Trough FEV1 was defined as the average of measurements made 23 hours 15 minutes and 23 hours 45 minutes post-dose. The analysis included baseline FEV1 measurement, baseline inhaled corticosteroid use (Yes/No), FEV1 prior to inhalation of short-acting β2 agonist (SABA), and FEV1 45 min post-inhalation of SABA as covariates.

Secondary

Measure	Time frame	Description
Health-related Quality of Life (QoL) Assessed With the St. George Respiratory Questionnaire (SGRQ) at Week 52	Week 52	The SGRQ contained 51 patient-rated items divided into three components: Symptoms (respiratory symptoms, their frequency, and severity), Activity (activities that cause or are limited by breathlessness), and Impacts (social functioning and psychological disturbances resulting from airway disease). A total score for the 3 components was calculated and ranged from 0 to 100. Higher values indicate greater impairment of QoL. The analysis included the same covariates as the primary Outcome Measure.
Time to First Moderate or Severe Chronic Obstructive Pulmonary Disease (COPD) Exacerbation During the Study (Baseline to Week 52)	Baseline to Week 52 (patients with no moderate or severe exacerbations who completed the study were censored at the final visit date, which may have exceeded 52 weeks)	Time to first moderate or severe COPD exacerbation was calculated as the number of days from baseline to the day on which the patient experienced the first moderate or severe COPD exacerbation. A COPD exacerbation was considered to be moderate if treatment with systemic corticosteroids and/or antibiotic was required. A COPD exacerbation was considered to be severe if treatment for moderate severity and hospitalization was required.
Change From Baseline in the Mean Daily Number of Puffs of Rescue Medication Taken During the Study (Baseline to Week 52)	Baseline to Week 52	The number of puffs of rescue medication taken in the previous 12 hours was recorded in the Patient Diary in the morning and evening. The mean daily number of puffs of rescue medication taken was calculated by dividing the number of puffs of rescue medication per day over the 52 weeks of the study by the number of days with non-missing rescue medication data. Rescue medication data recorded during the 14 day run-in period was used to calculate the baseline. The analysis included the same covariates as the primary Outcome Measure. A positive change score indicates more puffs taken.
Trough Forced Expiratory Volume in 1 Second (FEV1) at Day 1, Week 26, and Week 52	Day 1, Week 26, and Week 52	FEV1 was measured with spirometry conducted according to internationally accepted standards. Trough FEV1 was defined as the average of measurements made 23 hours 15 minutes and 23 hours 45 minutes post-dose. The analysis included the same covariates as the primary Outcome Measure.
Trough Forced Vital Capacity (FVC) at Day 1, Week 12, Week 26, and Week 52	Day 1, Week 12, Week 26, and Week 52	Trough FVC is defined as the average of the post-dose 23 h 15 min and the 23 h 45 min FVC values. Just prior to FVC measurement, patients performed normal tidal breathing. The patient was given a few breaths warning before being told At the end of the next normal breath out, take a deep breath all the way in; they were then verbally encouraged to make a maximal effort before relaxing. The analysis included the same covariates as the primary Outcome Measure.
Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	5, 15, and 30 minutes; 1, 2, 3, 4, 6, 8, 10, and 12 hours; 23 hours 15 minutes; and 23 hours 45 minutes post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	FEV1 was measured with spirometry conducted according to internationally accepted standards. The analysis included the same covariates as the primary Outcome Measure. Data was not collected at all time points for all Days and Weeks.
Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	5, 15, and 30 minutes; 1, 2, 3, 4, 6, 8, 10, and 12 hours; 23 hours 15 minutes; and 23 hours 45 minutes post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Just prior to FVC measurement, patients performed normal tidal breathing. The patient was given a few breaths warning before being told At the end of the next normal breath out, take a deep breath all the way in; they were then verbally encouraged to make a maximal effort before relaxing. The analysis included the same covariates as the primary Outcome Measure. Data was not collected at all time points for all Days and Weeks.
Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	5, 15, and 30 minutes; and 1, 2, 3, 4 hours post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	FEV1 was measured with spirometry conducted according to internationally accepted standards. The analysis included the same covariates as the primary Outcome Measure. Data was not collected at all time points for all Days and Weeks.
Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	5, 15, and 30 minutes; and 1, 2, 3, 4 hours post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Just prior to FVC measurement, patients performed normal tidal breathing. The patient was given a few breaths warning before being told At the end of the next normal breath out, take a deep breath all the way in; they were then verbally encouraged to make a maximal effort before relaxing. The analysis included the same covariates as the primary Outcome Measure. Data was not collected at all time points for all Days and Weeks.
Transition Dyspnea Index (TDI) at Week 26	Week 26	The TDI measured changes in dyspnea from baseline during treatment and included 3 domains: Functional impairment (activities of daily living), magnitude of task (intensity of activity), and magnitude of effort (difficulty breathing). Each domain was rated from -3 to 3 (major deterioration-major improvement). The total score ranged from -9 to 9; minus scores indicate deterioration. The analysis included the same covariates as the primary Outcome Measure.
Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 12 Hours Post-dose at Day 1 and Weeks 12 and 52	From 5 minutes to 12 hours post-dose at Day 1 and Weeks 12 and 52	FEV1 was measured with spirometry conducted according to internationally accepted standards. Measurements were made at 5, 15, and 30 minutes; and 1, 2, 3, 4, 6, 8 10, and 12 hours post-dose. Standardized FEV1 AUC was calculated by the trapezoidal rule. The analysis included the same covariates as the primary Outcome Measure.
Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 23 Hours 45 Minutes and From 12 Hours to 23 Hours 45 Minutes Post-dose at Weeks 12 and 52	From 5 minutes to 23 hours 45 minutes post-dose at Weeks 12 and 52	FEV1 was measured with spirometry conducted according to internationally accepted standards. Measurements were made at 5, 15, and 30 minutes; 1, 2, 3, 4, 6, 8, 10, and 12 hours; 23 hours 15 minutes; and 23 hours 45 minutes post-dose. Standardized FEV1 AUC was calculated by the trapezoidal rule. The analysis included the same covariates as the primary Outcome Measure.
Number of Moderate or Severe Exacerbations of Chronic Obstructive Pulmonary Disease (COPD) Per Year During the Study (Baseline to Week 52)	Baseline to Week 52	The number of moderate or severe exacerbations of COPD per year during the study was calculated by dividing the total number of exacerbations during the study by the total number of years of treatment. A COPD exacerbation was considered to be moderate if treatment with systemic corticosteroids and/or antibiotic was required. A COPD exacerbation was considered to be severe if treatment for moderate severity and hospitalization was required.
Percentage of Patients Who Experienced a Moderate or Severe Chronic Obstructive Pulmonary Disease (COPD) Exacerbation During the Study (Baseline to Week 52)	Baseline to Week 52	A COPD exacerbation was considered to be moderate if treatment with systemic corticosteroids and/or antibiotic was required. A COPD exacerbation was considered to be severe if treatment for moderate severity and hospitalization was required.
Percentage of Nights With no Nighttime Awakenings During the Study (Baseline to Week 52)	Baseline to Week 52	A night with no nighttime awakenings was defined as any night where the patient did not wake up due to 1 or more of 6 symptoms (respiratory symptoms, cough, wheeze, amount of sputum, color of sputum, and breathlessness). Symptoms occurring during the previous 12 hours were recorded each morning and evening by the patient in an electronic diary. The percentage of nights with 'no nighttime awakenings' was calculated as the total number of nights with no nighttime awakenings over the 52 week treatment period divided by the total number of nights where diary recordings were made.
Percentage of Days With no Daytime Symptoms During the Study (Baseline to Week 52)	Baseline to Week 52	A day with no daytime symptoms was defined as any day where the patient recorded no cough, no wheeze, no production of sputum, no feeling of breathlessness (other than when running), and no puffs of rescue medication during the previous 12 hours in evening entry in the electronic patient diary. The percentage of days with no daytime symptoms was calculated as the total number of days with no daytime symptoms over the 52 week treatment period divided by the total number of days where diary recordings were made.
Percentage of Days Able to Perform Usual Daily Activities During the Study (Baseline to Week 52)	Baseline to Week 52	A day able to perform usual daily activities was defined as any day where the patient recorded in their electronic diary in the evening that they were not prevented from performing their usual daily activities due to respiratory symptoms during the previous 12 hours. The percentage of days able to perform usual daily activities was calculated as the total number of days able to perform usual daily activities over the 52 week treatment period divided by the total number of days where diary recordings were made.
Change From Baseline in the Mean Daily Total Symptom Score During the Study (Baseline to Week 52)	Baseline to Week 52	The daily total symptom score was defined as the sum of the morning and evening patient self-reported diary assessments of 6 symptoms (respiratory symptoms/impact on daily activities, cough, wheeze, amount of sputum, color of sputum, and breathlessness). Means for baseline (14 day maximum run-in period) and the 52 week treatment period were calculated. Mean scores ranged from 0-18, with a higher score indicating worse symptoms. A negative change score indicated improvement.
Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 4 Hours Post-dose at Day 1 and Weeks 12, 26, and 52	From 5 minutes to 4 hours post-dose at Day 1 and Weeks 12, 26, and 52	FEV1 was measured with spirometry conducted according to internationally accepted standards. Measurements were made at 5, 15, and 30 minutes; and 1, 2, 3, and 4 hours post-dose. Standardized FEV1 AUC was calculated by the trapezoidal rule. The analysis included the same covariates as the primary Outcome Measure.

Countries

Argentina, Canada, Chile, France, Germany, Hungary, Israel, Italy, Mexico, Netherlands, New Zealand, Peru, Poland, Russia, South Korea, United States

Participant flow

Recruitment details

A total of 1993 patients were screened from 180 participating sites, of whom 1066 were randomized to 1 of the 3 treatment groups in a 2:1:1 ratio glycopyrronium bromide:placebo:tiotropium.

Participants by arm

Arm	Count
Glycopyrronium Bromide 50 μg Patients inhaled glycopyrronium bromide 50 μg once daily in the morning between 8:00 AM and 10:00 AM via a single-dose dry-powder inhaler (SDDPI) for 52 weeks. Daily inhaled corticosteroid treatment (if applicable) was to remain stable throughout the study. The short-acting β2-agonist salbutamol/albuterol was available for rescue use throughout the study.	525
Placebo to Glycopyrronium Bromide Patients inhaled placebo to glycopyrronium bromide once daily in the morning between 8:00 AM and 10:00 AM via a single-dose dry-powder inhaler (SDDPI) for 52 weeks. Daily inhaled corticosteroid treatment (if applicable) was to remain stable throughout the study. The short-acting β2-agonist salbutamol/albuterol was available for rescue use throughout the study.	268
Tiotropium 18 μg Patients inhaled tiotropium 18 μg once daily in the morning between 8:00 AM and 10:00 AM via a single-dose dry-powder inhaler (SDDPI) for 52 weeks. Daily inhaled corticosteroid treatment (if applicable) was to remain stable throughout the study. The short-acting β2-agonist salbutamol/albuterol was available for rescue use throughout the study.	267
Total	1,060

Withdrawals & dropouts

Period	Reason	FG000	FG001	FG002
Overall Study	Abnormal laboratory value(s)	0	1	0
Overall Study	Abnormal test procedure result(s)	0	1	1
Overall Study	Administrative problems	4	1	2
Overall Study	Adverse Event	40	29	18
Overall Study	Death	2	2	2
Overall Study	Lost to Follow-up	7	7	3
Overall Study	Patient inability to use the device	0	1	0
Overall Study	Protocol deviation	5	2	4
Overall Study	Subject withdrew consent	40	23	26
Overall Study	Unsatisfactory therapeutic effect	20	9	6

Baseline characteristics

Characteristic	Glycopyrronium Bromide 50 μg	Placebo to Glycopyrronium Bromide	Tiotropium 18 μg	Total
Age Continuous	63.5 years STANDARD_DEVIATION 9.05	63.6 years STANDARD_DEVIATION 9.14	63.9 years STANDARD_DEVIATION 8.25	63.6 years STANDARD_DEVIATION 8.87
Sex: Female, Male Female	186 Participants	95 Participants	99 Participants	380 Participants
Sex: Female, Male Male	339 Participants	173 Participants	168 Participants	680 Participants

Adverse events

Event type	EG000 affected / at risk	EG001 affected / at risk	EG002 affected / at risk
deaths Total, all-cause mortality	— / —	— / —	— / —
other Total, other adverse events	305 / 525	164 / 268	156 / 267
serious Total, serious adverse events	65 / 525	43 / 268	40 / 267

Outcome results

Primary

Trough Forced Expiratory Volume in 1 Second (FEV1) at Week 12

FEV1 was measured with spirometry conducted according to internationally accepted standards. Trough FEV1 was defined as the average of measurements made 23 hours 15 minutes and 23 hours 45 minutes post-dose. The analysis included baseline FEV1 measurement, baseline inhaled corticosteroid use (Yes/No), FEV1 prior to inhalation of short-acting β2 agonist (SABA), and FEV1 45 min post-inhalation of SABA as covariates.

Time frame: Week 12

Population: Full Analysis Set (FAS): All randomized patients who received at least 1 dose of study medication.

Arm	Measure	Value (LEAST_SQUARES_MEAN)	Dispersion
Glycopyrronium Bromide 50 μg	Trough Forced Expiratory Volume in 1 Second (FEV1) at Week 12	1.469 Liters	Standard Error 0.0141
Placebo to Glycopyrronium Bromide	Trough Forced Expiratory Volume in 1 Second (FEV1) at Week 12	1.372 Liters	Standard Error 0.0173
Tiotropium 18 μg	Trough Forced Expiratory Volume in 1 Second (FEV1) at Week 12	1.455 Liters	Standard Error 0.017

Secondary

Change From Baseline in the Mean Daily Number of Puffs of Rescue Medication Taken During the Study (Baseline to Week 52)

The number of puffs of rescue medication taken in the previous 12 hours was recorded in the Patient Diary in the morning and evening. The mean daily number of puffs of rescue medication taken was calculated by dividing the number of puffs of rescue medication per day over the 52 weeks of the study by the number of days with non-missing rescue medication data. Rescue medication data recorded during the 14 day run-in period was used to calculate the baseline. The analysis included the same covariates as the primary Outcome Measure. A positive change score indicates more puffs taken.

Time frame: Baseline to Week 52

Population: Full Analysis Set (FAS): All randomized patients who received at least 1 dose of study medication.

Arm	Measure	Value (LEAST_SQUARES_MEAN)	Dispersion
Glycopyrronium Bromide 50 μg	Change From Baseline in the Mean Daily Number of Puffs of Rescue Medication Taken During the Study (Baseline to Week 52)	-1.58 Puffs	Standard Error 0.151
Placebo to Glycopyrronium Bromide	Change From Baseline in the Mean Daily Number of Puffs of Rescue Medication Taken During the Study (Baseline to Week 52)	-1.20 Puffs	Standard Error 0.184
Tiotropium 18 μg	Change From Baseline in the Mean Daily Number of Puffs of Rescue Medication Taken During the Study (Baseline to Week 52)	-1.83 Puffs	Standard Error 0.183

Secondary

Change From Baseline in the Mean Daily Total Symptom Score During the Study (Baseline to Week 52)

The daily total symptom score was defined as the sum of the morning and evening patient self-reported diary assessments of 6 symptoms (respiratory symptoms/impact on daily activities, cough, wheeze, amount of sputum, color of sputum, and breathlessness). Means for baseline (14 day maximum run-in period) and the 52 week treatment period were calculated. Mean scores ranged from 0-18, with a higher score indicating worse symptoms. A negative change score indicated improvement.

Time frame: Baseline to Week 52

Population: Full Analysis Set (FAS): All randomized patients who received at least 1 dose of study medication.

Arm	Measure	Value (LEAST_SQUARES_MEAN)	Dispersion
Glycopyrronium Bromide 50 μg	Change From Baseline in the Mean Daily Total Symptom Score During the Study (Baseline to Week 52)	-1.85 Units on a scale	Standard Error 0.125
Placebo to Glycopyrronium Bromide	Change From Baseline in the Mean Daily Total Symptom Score During the Study (Baseline to Week 52)	-1.42 Units on a scale	Standard Error 0.149
Tiotropium 18 μg	Change From Baseline in the Mean Daily Total Symptom Score During the Study (Baseline to Week 52)	-1.87 Units on a scale	Standard Error 0.149

Secondary

Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52

FEV1 was measured with spirometry conducted according to internationally accepted standards. The analysis included the same covariates as the primary Outcome Measure. Data was not collected at all time points for all Days and Weeks.

Time frame: 5, 15, and 30 minutes; 1, 2, 3, 4, 6, 8, 10, and 12 hours; 23 hours 15 minutes; and 23 hours 45 minutes post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52

Population: Full Analysis Set (FAS), serial spirometry subgroup: A subgroup of approximately one third of all randomized patients who received at least 1 dose of study medication.

Arm	Measure	Group	Value (LEAST_SQUARES_MEAN)	Dispersion
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 12 (n=130, 69, 70)	1.522 Liters	Standard Error 0.0254
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 30 (n=123, 61, 58)	1.537 Liters	Standard Error 0.0332
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 4 (n=124, 64, 68)	1.584 Liters	Standard Error 0.0319
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 2 (n=144, 75, 75)	1.639 Liters	Standard Error 0.0202
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 15 (n=123, 61, 58)	1.520 Liters	Standard Error 0.0305
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 6 (n=123, 63, 69)	1.558 Liters	Standard Error 0.0321
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 15 (n=126, 66, 67)	1.518 Liters	Standard Error 0.0269
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 8 (n=121, 64, 69)	1.535 Liters	Standard Error 0.031
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 5 (n=119, 61, 58)	1.512 Liters	Standard Error 0.0305
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 10 (n=124, 61, 69)	1.541 Liters	Standard Error 0.0296
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 15 (n=129, 71, 72)	1.471 Liters	Standard Error 0.0214
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, hour 1 (n=125, 62, 63)	1.557 Liters	Standard Error 0.0285
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 12 (n=122, 58, 68)	1.522 Liters	Standard Error 0.0313
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 30 (n=125, 62, 62)	1.567 Liters	Standard Error 0.0302
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 15 (n=123, 62, 63)	1.529 Liters	Standard Error 0.03
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 22 (n=117, 60, 63)	1.420 Liters	Standard Error 0.0268
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 16 (n=117, 53, 46)	1.377 Liters	Standard Error 0.0309
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 5 (n=125, 62, 63)	1.515 Liters	Standard Error 0.0293
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 16 (n=109, 56, 57)	1.431 Liters	Standard Error 0.032
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 45 (n=117, 56, 61)	1.483 Liters	Standard Error 0.0296
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 45 (n=124, 65, 63)	1.513 Liters	Standard Error 0.0294
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 45 (n=128, 74, 75)	1.518 Liters	Standard Error 0.021
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 15 (n=120, 55, 61)	1.477 Liters	Standard Error 0.0323
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 5 (n=123, 65, 64)	1.538 Liters	Standard Error 0.0296
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 15 (n=124, 65, 65)	1.557 Liters	Standard Error 0.0309
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, 15 minutes (n=121, 62, 57)	1.447 Liters	Standard Error 0.0287
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 4 (n=124, 64, 62)	1.577 Liters	Standard Error 0.0304
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 30 (n=125, 65, 65)	1.570 Liters	Standard Error 0.0303
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 15 (n=129, 67, 66)	1.523 Liters	Standard Error 0.0251
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 3 (n=124, 64, 64)	1.614 Liters	Standard Error 0.0303
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 5 (n=125, 66, 63)	1.518 Liters	Standard Error 0.0281
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 5 (n=135, 65, 73)	1.494 Liters	Standard Error 0.0246
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 2 (n=124, 64, 63)	1.590 Liters	Standard Error 0.0317
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 15 (n=124, 65, 63)	1.535 Liters	Standard Error 0.0285
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 1 (n=127, 64, 64)	1.546 Liters	Standard Error 0.0275
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 30 (n=125, 65, 63)	1.576 Liters	Standard Error 0.0277
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 3 (n=143, 74, 73)	1.629 Liters	Standard Error 0.0199
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 30 (n=125, 64, 64)	1.529 Liters	Standard Error 0.0285
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 5 (n=123, 62, 64)	1.483 Liters	Standard Error 0.0278
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 15 (n=139, 75, 74)	1.548 Liters	Standard Error 0.0152
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 15 (n=121, 61, 61)	1.521 Liters	Standard Error 0.028
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 15 (n=136, 67, 70)	1.575 Liters	Standard Error 0.0239
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 10 (n=119, 59, 55)	1.478 Liters	Standard Error 0.0304
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 30 (n= 139, 70, 74)	1.551 Liters	Standard Error 0.0236
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, hour 1 (n=140, 68, 74)	1.575 Liters	Standard Error 0.0242
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 4 (n=144, 70, 74)	1.599 Liters	Standard Error 0.0221
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 15 (n=133, 70, 72)	1.530 Liters	Standard Error 0.0246
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 5 (n=134, 66, 68)	1.550 Liters	Standard Error 0.0247
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 12 (n=120, 58, 52)	1.451 Liters	Standard Error 0.0334
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 4 (n=121, 60, 55)	1.535 Liters	Standard Error 0.0297
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 30 (n=143, 77, 74)	1.561 Liters	Standard Error 0.018
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 30 (n=135, 67, 70)	1.630 Liters	Standard Error 0.026
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 6 (n=142, 71, 74)	1.578 Liters	Standard Error 0.0204
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 8 (n=119, 59, 54)	1.473 Liters	Standard Error 0.03
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 5 (n=128, 66, 70)	1.562 Liters	Standard Error 0.0268
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 1 (n=144, 76, 75)	1.583 Liters	Standard Error 0.0172
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 6 (n=118, 59, 54)	1.494 Liters	Standard Error 0.0294
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 15 (n=130, 66, 71)	1.583 Liters	Standard Error 0.0267
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 15 (n=122, 59, 58)	1.502 Liters	Standard Error 0.0282
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 3 (n=123, 62, 56)	1.558 Liters	Standard Error 0.0263
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 30 (n=130, 67, 71)	1.603 Liters	Standard Error 0.0265
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 8 (n=137, 70, 75)	1.544 Liters	Standard Error 0.0226
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 2 (n=124, 61, 58)	1.554 Liters	Standard Error 0.0295
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 5 (n=130, 69, 70)	1.497 Liters	Standard Error 0.0254
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 22 (n=118, 60, 52)	1.391 Liters	Standard Error 0.0302
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 5 (n=135, 74, 74)	1.494 Liters	Standard Error 0.0135
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 5 (n=124, 60, 57)	1.456 Liters	Standard Error 0.0276
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 1 (n=125, 62, 57)	1.525 Liters	Standard Error 0.0271
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 30 (n=133, 69, 67)	1.517 Liters	Standard Error 0.0275
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day1, hour 10 (n=134, 72, 75)	1.546 Liters	Standard Error 0.0235
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 30 (n=125, 62, 58)	1.483 Liters	Standard Error 0.028
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 1 (n=132, 67, 69)	1.557 Liters	Standard Error 0.0273
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, 45 minutes (n=122, 61, 57)	1.434 Liters	Standard Error 0.0281
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 30 (n=123, 60, 58)	1.545 Liters	Standard Error 0.0287
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 2 (n=129, 65, 68)	1.596 Liters	Standard Error 0.029
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 5 (n=120, 60, 57)	1.490 Liters	Standard Error 0.0269
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 15 (n=123, 60, 57)	1.529 Liters	Standard Error 0.0285
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 3 (n=126, 64, 69)	1.600 Liters	Standard Error 0.0291
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 1 (n=125, 62, 57)	1.356 Liters	Standard Error 0.0359
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 5 (n=135, 74, 74)	1.416 Liters	Standard Error 0.0166
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 15 (n=139, 75, 74)	1.428 Liters	Standard Error 0.0185
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 30 (n=143, 77, 74)	1.409 Liters	Standard Error 0.0218
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 1 (n=144, 76, 75)	1.404 Liters	Standard Error 0.0213
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 2 (n=144, 75, 75)	1.445 Liters	Standard Error 0.0248
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 3 (n=143, 74, 73)	1.435 Liters	Standard Error 0.0249
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 4 (n=144, 70, 74)	1.415 Liters	Standard Error 0.0281
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 6 (n=142, 71, 74)	1.426 Liters	Standard Error 0.0255
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 8 (n=137, 70, 75)	1.431 Liters	Standard Error 0.0284
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day1, hour 10 (n=134, 72, 75)	1.415 Liters	Standard Error 0.029
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 12 (n=130, 69, 70)	1.369 Liters	Standard Error 0.0307
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 15 (n=129, 71, 72)	1.396 Liters	Standard Error 0.0259
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 45 (n=128, 74, 75)	1.446 Liters	Standard Error 0.0252
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 5 (n=135, 65, 73)	1.421 Liters	Standard Error 0.0315
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 15 (n=133, 70, 72)	1.411 Liters	Standard Error 0.0307
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 30 (n= 139, 70, 74)	1.417 Liters	Standard Error 0.0297
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, hour 1 (n=140, 68, 74)	1.409 Liters	Standard Error 0.0305
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 5 (n=134, 66, 68)	1.448 Liters	Standard Error 0.0319
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 15 (n=136, 67, 70)	1.452 Liters	Standard Error 0.0305
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 30 (n=135, 67, 70)	1.481 Liters	Standard Error 0.0327
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 5 (n=128, 66, 70)	1.417 Liters	Standard Error 0.0341
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 15 (n=130, 66, 71)	1.441 Liters	Standard Error 0.034
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 30 (n=130, 67, 71)	1.427 Liters	Standard Error 0.0335
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 5 (n=130, 69, 70)	1.385 Liters	Standard Error 0.0319
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 15 (n=129, 67, 66)	1.373 Liters	Standard Error 0.0317
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 30 (n=133, 69, 67)	1.362 Liters	Standard Error 0.0336
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 1 (n=132, 67, 69)	1.369 Liters	Standard Error 0.0341
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 2 (n=129, 65, 68)	1.434 Liters	Standard Error 0.0365
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 3 (n=126, 64, 69)	1.443 Liters	Standard Error 0.0375
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 4 (n=124, 64, 68)	1.442 Liters	Standard Error 0.0407
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 6 (n=123, 63, 69)	1.443 Liters	Standard Error 0.0407
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 10 (n=124, 61, 69)	1.435 Liters	Standard Error 0.0392
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 22 (n=117, 60, 63)	1.349 Liters	Standard Error 0.035
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 15 (n=126, 66, 67)	1.456 Liters	Standard Error 0.0345
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 45 (n=124, 65, 63)	1.470 Liters	Standard Error 0.0377
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 15 (n=124, 65, 65)	1.422 Liters	Standard Error 0.038
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 30 (n=125, 65, 65)	1.409 Liters	Standard Error 0.037
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 5 (n=125, 66, 63)	1.393 Liters	Standard Error 0.0348
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 30 (n=125, 65, 63)	1.391 Liters	Standard Error 0.0349
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 5 (n=123, 62, 64)	1.361 Liters	Standard Error 0.0368
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 15 (n=121, 61, 61)	1.377 Liters	Standard Error 0.0373
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 1 (n=127, 64, 64)	1.364 Liters	Standard Error 0.0359
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 2 (n=124, 64, 63)	1.422 Liters	Standard Error 0.0403
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 3 (n=124, 64, 64)	1.442 Liters	Standard Error 0.0391
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 4 (n=124, 64, 62)	1.416 Liters	Standard Error 0.0384
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 15 (n=120, 55, 61)	1.374 Liters	Standard Error 0.0422
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 45 (n=117, 56, 61)	1.401 Liters	Standard Error 0.0395
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 5 (n=125, 62, 63)	1.359 Liters	Standard Error 0.0385
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 15 (n=123, 62, 63)	1.360 Liters	Standard Error 0.0394
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 30 (n=125, 62, 62)	1.353 Liters	Standard Error 0.0398
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, hour 1 (n=125, 62, 63)	1.352 Liters	Standard Error 0.0376
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 30 (n=123, 61, 58)	1.391 Liters	Standard Error 0.0431
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 5 (n=120, 60, 57)	1.357 Liters	Standard Error 0.0348
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 15 (n=123, 60, 57)	1.375 Liters	Standard Error 0.0369
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 30 (n=123, 60, 58)	1.368 Liters	Standard Error 0.0375
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 30 (n=125, 62, 58)	1.366 Liters	Standard Error 0.037
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 2 (n=124, 61, 58)	1.418 Liters	Standard Error 0.0393
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 4 (n=121, 60, 55)	1.381 Liters	Standard Error 0.0395
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 6 (n=118, 59, 54)	1.370 Liters	Standard Error 0.0392
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 8 (n=119, 59, 54)	1.358 Liters	Standard Error 0.0398
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 8 (n=121, 64, 69)	1.408 Liters	Standard Error 0.0385
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 12 (n=122, 58, 68)	1.422 Liters	Standard Error 0.0417
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 16 (n=109, 56, 57)	1.360 Liters	Standard Error 0.0425
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 5 (n=123, 65, 64)	1.430 Liters	Standard Error 0.0362
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 15 (n=124, 65, 63)	1.380 Liters	Standard Error 0.0354
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 30 (n=125, 64, 64)	1.353 Liters	Standard Error 0.0372
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 5 (n=119, 61, 58)	1.394 Liters	Standard Error 0.0401
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 15 (n=123, 61, 58)	1.412 Liters	Standard Error 0.0403
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 5 (n=124, 60, 57)	1.337 Liters	Standard Error 0.0368
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 15 (n=122, 59, 58)	1.380 Liters	Standard Error 0.0378
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 3 (n=123, 62, 56)	1.384 Liters	Standard Error 0.0349
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 10 (n=119, 59, 55)	1.349 Liters	Standard Error 0.0397
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, 15 minutes (n=121, 62, 57)	1.362 Liters	Standard Error 0.0378
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, 45 minutes (n=122, 61, 57)	1.337 Liters	Standard Error 0.0372
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 12 (n=120, 58, 52)	1.369 Liters	Standard Error 0.0446
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 16 (n=117, 53, 46)	1.277 Liters	Standard Error 0.0422
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 22 (n=118, 60, 52)	1.314 Liters	Standard Error 0.0397
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 4 (n=124, 64, 68)	1.535 Liters	Standard Error 0.0383
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 15 (n=123, 61, 58)	1.491 Liters	Standard Error 0.0396
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 3 (n=126, 64, 69)	1.566 Liters	Standard Error 0.0353
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, 45 minutes (n=122, 61, 57)	1.359 Liters	Standard Error 0.0364
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 30 (n=123, 61, 58)	1.517 Liters	Standard Error 0.0424
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 6 (n=142, 71, 74)	1.575 Liters	Standard Error 0.0252
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 5 (n=120, 60, 57)	1.422 Liters	Standard Error 0.0341
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 2 (n=129, 65, 68)	1.565 Liters	Standard Error 0.0353
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 12 (n=120, 58, 52)	1.347 Liters	Standard Error 0.0444
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 15 (n=123, 60, 57)	1.452 Liters	Standard Error 0.0362
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 1 (n=132, 67, 69)	1.519 Liters	Standard Error 0.0333
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 2 (n=124, 61, 58)	1.479 Liters	Standard Error 0.0382
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 30 (n=123, 60, 58)	1.470 Liters	Standard Error 0.0366
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 5 (n=124, 60, 57)	1.377 Liters	Standard Error 0.0359
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 15 (n=122, 59, 58)	1.428 Liters	Standard Error 0.0364
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 30 (n=133, 69, 67)	1.488 Liters	Standard Error 0.0335
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 15 (n=139, 75, 74)	1.485 Liters	Standard Error 0.0185
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 30 (n=125, 62, 58)	1.407 Liters	Standard Error 0.0362
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 15 (n=129, 67, 66)	1.481 Liters	Standard Error 0.0315
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 5 (n=130, 69, 70)	1.474 Liters	Standard Error 0.0315
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 1 (n=125, 62, 57)	1.439 Liters	Standard Error 0.0352
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 30 (n=130, 67, 71)	1.549 Liters	Standard Error 0.0323
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 3 (n=123, 62, 56)	1.487 Liters	Standard Error 0.0345
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 15 (n=130, 66, 71)	1.534 Liters	Standard Error 0.0326
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 4 (n=144, 70, 74)	1.560 Liters	Standard Error 0.0275
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 4 (n=121, 60, 55)	1.468 Liters	Standard Error 0.039
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 5 (n=128, 66, 70)	1.520 Liters	Standard Error 0.0326
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 6 (n=118, 59, 54)	1.461 Liters	Standard Error 0.0388
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 30 (n=135, 67, 70)	1.584 Liters	Standard Error 0.0317
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 8 (n=119, 59, 54)	1.418 Liters	Standard Error 0.0394
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 10 (n=119, 59, 55)	1.419 Liters	Standard Error 0.0391
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 15 (n=136, 67, 70)	1.543 Liters	Standard Error 0.0295
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 5 (n=135, 65, 73)	1.490 Liters	Standard Error 0.0299
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, hour 1 (n=140, 68, 74)	1.540 Liters	Standard Error 0.0296
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 30 (n= 139, 70, 74)	1.516 Liters	Standard Error 0.0289
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 5 (n=134, 66, 68)	1.525 Liters	Standard Error 0.0305
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 15 (n=133, 70, 72)	1.537 Liters	Standard Error 0.0303
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 45 (n=128, 74, 75)	1.499 Liters	Standard Error 0.0249
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 6 (n=123, 63, 69)	1.520 Liters	Standard Error 0.0381
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 3 (n=143, 74, 73)	1.587 Liters	Standard Error 0.0248
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, 15 minutes (n=121, 62, 57)	1.387 Liters	Standard Error 0.0371
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 5 (n=123, 62, 64)	1.415 Liters	Standard Error 0.0352
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 15 (n=129, 71, 72)	1.481 Liters	Standard Error 0.0255
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 15 (n=121, 61, 61)	1.464 Liters	Standard Error 0.0358
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 30 (n=125, 65, 63)	1.502 Liters	Standard Error 0.035
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 30 (n=125, 64, 64)	1.439 Liters	Standard Error 0.0359
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 15 (n=124, 65, 63)	1.479 Liters	Standard Error 0.0356
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 22 (n=118, 60, 52)	1.282 Liters	Standard Error 0.0396
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 1 (n=127, 64, 64)	1.462 Liters	Standard Error 0.0349
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 5 (n=125, 66, 63)	1.453 Liters	Standard Error 0.0351
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 12 (n=130, 69, 70)	1.480 Liters	Standard Error 0.0306
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 2 (n=124, 64, 63)	1.520 Liters	Standard Error 0.0395
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 30 (n=125, 65, 65)	1.535 Liters	Standard Error 0.0368
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 2 (n=144, 75, 75)	1.569 Liters	Standard Error 0.0247
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 3 (n=124, 64, 64)	1.555 Liters	Standard Error 0.038
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 15 (n=124, 65, 65)	1.530 Liters	Standard Error 0.0377
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 5 (n=123, 65, 64)	1.515 Liters	Standard Error 0.0359
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 4 (n=124, 64, 62)	1.519 Liters	Standard Error 0.0377
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 45 (n=124, 65, 63)	1.488 Liters	Standard Error 0.0374
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 16 (n=117, 53, 46)	1.329 Liters	Standard Error 0.042
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 15 (n=120, 55, 61)	1.416 Liters	Standard Error 0.0399
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 15 (n=126, 66, 67)	1.520 Liters	Standard Error 0.0335
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 1 (n=144, 76, 75)	1.514 Liters	Standard Error 0.0212
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 45 (n=117, 56, 61)	1.405 Liters	Standard Error 0.0376
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 22 (n=117, 60, 63)	1.371 Liters	Standard Error 0.0333
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 5 (n=135, 74, 74)	1.447 Liters	Standard Error 0.0164
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 5 (n=125, 62, 63)	1.407 Liters	Standard Error 0.0372
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 16 (n=109, 56, 57)	1.378 Liters	Standard Error 0.0404
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 30 (n=143, 77, 74)	1.483 Liters	Standard Error 0.0219
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 15 (n=123, 62, 63)	1.425 Liters	Standard Error 0.0379
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 12 (n=122, 58, 68)	1.487 Liters	Standard Error 0.0382
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day1, hour 10 (n=134, 72, 75)	1.537 Liters	Standard Error 0.0286
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 30 (n=125, 62, 62)	1.452 Liters	Standard Error 0.0385
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 10 (n=124, 61, 69)	1.532 Liters	Standard Error 0.0365
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 8 (n=137, 70, 75)	1.545 Liters	Standard Error 0.0278
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, hour 1 (n=125, 62, 63)	1.472 Liters	Standard Error 0.0361
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 8 (n=121, 64, 69)	1.479 Liters	Standard Error 0.0374
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 5 (n=119, 61, 58)	1.490 Liters	Standard Error 0.0394

Secondary

Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52

Time frame: 5, 15, and 30 minutes; and 1, 2, 3, 4 hours post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52

Population: Full Analysis Set (FAS): All randomized patients who received at least 1 dose of study medication.

Arm	Measure	Group	Value (LEAST_SQUARES_MEAN)	Dispersion
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 3 (n=400, 186, 199)	1.525 Liters	Standard Error 0.0171
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 15 (n=430, 207, 220)	1.525 Liters	Standard Error 0.0164
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 30 (n=433, 209, 220)	1.546 Liters	Standard Error 0.016
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 2 (n=402, 186, 202)	1.526 Liters	Standard Error 0.0177
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 30 (n=431, 207, 221)	1.544 Liters	Standard Error 0.0164
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 15 (n=479, 222, 234)	1.538 Liters	Standard Error 0.0126
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 1 (n=404, 190, 201)	1.499 Liters	Standard Error 0.0161
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 5 (421, 202, 213)	1.479 Liters	Standard Error 0.0153
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 30 (n=402, 189, 202)	1.471 Liters	Standard Error 0.0164
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 15 (n=394, 183, 200)	1.471 Liters	Standard Error 0.0159
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 15 (n=414, 200, 207)	1.504 Liters	Standard Error 0.0155
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 1 (n=511, 256, 254)	1.552 Liters	Standard Error 0.0082
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 30 (n=392, 186, 204)	1.504 Liters	Standard Error 0.0166
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 15 (n=391, 187, 203)	1.496 Liters	Standard Error 0.0156
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 1 (n=425, 206, 212)	1.541 Liters	Standard Error 0.016
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 15 (n=428, 209, 219)	1.530 Liters	Standard Error 0.0155
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 5 (n=386, 185, 199)	1.454 Liters	Standard Error 0.0155
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 2 (n=420, 203, 208)	1.570 Liters	Standard Error 0.0176
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 30 (n=480, 223, 234)	1.564 Liters	Standard Error 0.0129
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 3 (n=416, 204, 213)	1.570 Liters	Standard Error 0.0181
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 5 (n=498, 223, 243)	1.491 Liters	Standard Error 0.0123
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 30 (n=405, 189, 201)	1.518 Liters	Standard Error 0.0183
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 4 (n=416, 203, 208)	1.547 Liters	Standard Error 0.0175
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 5 (n=453, 212, 230)	1.502 Liters	Standard Error 0.0136
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 5 (n=454, 217, 227)	1.529 Liters	Standard Error 0.0126
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 15 (n=405, 188, 201)	1.511 Liters	Standard Error 0.0171
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 45 (n=401, 185, 198)	1.474 Liters	Standard Error 0.0175
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 15 (n=502, 255, 254)	1.501 Liters	Standard Error 0.0074
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 5 (n=398, 189, 199)	1.489 Liters	Standard Error 0.0172
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 15 (n=407, 191, 214)	1.508 Liters	Standard Error 0.0172
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 15 (n=459, 220, 225)	1.550 Liters	Standard Error 0.0132
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 30 (n=410, 196, 215)	1.518 Liters	Standard Error 0.0172
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 15 (n=487, 229, 239)	1.527 Liters	Standard Error 0.0123
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 30 (n=460, 220, 226)	1.569 Liters	Standard Error 0.0125
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 5 (n=401, 188, 197)	1.436 Liters	Standard Error 0.0155
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 15 (n=481, 243, 239)	1.459 Liters	Standard Error 0.0093
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 15 (n=448, 205, 222)	1.527 Liters	Standard Error 0.0131
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 5 (n=408, 194, 212)	1.481 Liters	Standard Error 0.0167
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 4 (n=504, 239, 250)	1.590 Liters	Standard Error 0.0095
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 30 (n=455, 212, 226)	1.522 Liters	Standard Error 0.0139
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 30 (n=503, 233, 242)	1.538 Liters	Standard Error 0.0122
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 3 (n=510, 248, 252)	1.590 Liters	Standard Error 0.0088
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 1 (n=455, 210, 227)	1.556 Liters	Standard Error 0.0139
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 2 (n=513, 253, 252)	1.612 Liters	Standard Error 0.009
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 30 (n=507, 252, 254)	1.524 Liters	Standard Error 0.0103
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 2 (n=446, 207, 225)	1.595 Liters	Standard Error 0.0145
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 15 (n=405, 187, 202)	1.464 Liters	Standard Error 0.0175
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 5 (n=495, 255, 253)	1.443 Liters	Standard Error 0.0067
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 3 (n=444, 204, 225)	1.592 Liters	Standard Error 0.0145
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 4 (n=437, 202, 224)	1.558 Liters	Standard Error 0.0152
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, hour 1 (n=501, 229, 240)	1.561 Liters	Standard Error 0.0121
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, minute 45 (n=395, 185, 199)	1.424 Liters	Standard Error 0.0165
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 15 (n=430, 200, 214)	1.481 Liters	Standard Error 0.0143
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, hour 1 (n=412, 195, 215)	1.534 Liters	Standard Error 0.0171
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, minute 15 (n=388, 183, 198)	1.419 Liters	Standard Error 0.0169
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 45 (n=426, 195, 205)	1.493 Liters	Standard Error 0.0149
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 5 (n=429, 207, 218)	1.514 Liters	Standard Error 0.0151
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 30 (n=424, 206, 213)	1.513 Liters	Standard Error 0.0161
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 5 (n=476, 221, 231)	1.509 Liters	Standard Error 0.0125
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 4 (n=397, 184, 199)	1.504 Liters	Standard Error 0.0176
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 5 (n=430, 206, 218)	1.495 Liters	Standard Error 0.0159
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 45 (n=474, 239, 232)	1.482 Liters	Standard Error 0.0094
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 5 (421, 202, 213)	1.339 Liters	Standard Error 0.0189
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 15 (n=502, 255, 254)	1.359 Liters	Standard Error 0.009
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 1 (n=511, 256, 254)	1.353 Liters	Standard Error 0.0101
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 45 (n=474, 239, 232)	1.390 Liters	Standard Error 0.0117
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 5 (n=498, 223, 243)	1.368 Liters	Standard Error 0.0157
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 15 (n=487, 229, 239)	1.371 Liters	Standard Error 0.0154
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 30 (n=503, 233, 242)	1.368 Liters	Standard Error 0.0152
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, hour 1 (n=501, 229, 240)	1.379 Liters	Standard Error 0.0153
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 5 (n=476, 221, 231)	1.371 Liters	Standard Error 0.0161
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 15 (n=479, 222, 234)	1.389 Liters	Standard Error 0.0162
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 30 (n=480, 223, 234)	1.396 Liters	Standard Error 0.0165
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 5 (n=454, 217, 227)	1.366 Liters	Standard Error 0.0159
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 5 (n=453, 212, 230)	1.349 Liters	Standard Error 0.0173
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 15 (n=448, 205, 222)	1.352 Liters	Standard Error 0.0171
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 30 (n=455, 212, 226)	1.352 Liters	Standard Error 0.0176
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 1 (n=455, 210, 227)	1.364 Liters	Standard Error 0.0178
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 2 (n=446, 207, 225)	1.423 Liters	Standard Error 0.0185
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 4 (n=437, 202, 224)	1.416 Liters	Standard Error 0.0193
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 15 (n=430, 200, 214)	1.381 Liters	Standard Error 0.0183
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 5 (n=429, 207, 218)	1.373 Liters	Standard Error 0.0185
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 30 (n=433, 209, 220)	1.372 Liters	Standard Error 0.0194
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 5 (n=430, 206, 218)	1.351 Liters	Standard Error 0.0198
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 15 (n=430, 207, 220)	1.362 Liters	Standard Error 0.0203
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 30 (n=431, 207, 221)	1.362 Liters	Standard Error 0.0203
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 15 (n=414, 200, 207)	1.340 Liters	Standard Error 0.0193
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 1 (n=425, 206, 212)	1.345 Liters	Standard Error 0.0193
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 2 (n=420, 203, 208)	1.388 Liters	Standard Error 0.0212
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 3 (n=416, 204, 213)	1.398 Liters	Standard Error 0.0216
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 4 (n=416, 203, 208)	1.384 Liters	Standard Error 0.0211
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 15 (n=405, 187, 202)	1.326 Liters	Standard Error 0.0217
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 45 (n=401, 185, 198)	1.354 Liters	Standard Error 0.0218
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 15 (n=407, 191, 214)	1.333 Liters	Standard Error 0.0215
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 5 (n=398, 189, 199)	1.342 Liters	Standard Error 0.0218
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 15 (n=405, 188, 201)	1.344 Liters	Standard Error 0.0218
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 30 (n=405, 189, 201)	1.350 Liters	Standard Error 0.0229
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 5 (n=386, 185, 199)	1.336 Liters	Standard Error 0.0197
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 15 (n=391, 187, 203)	1.341 Liters	Standard Error 0.0199
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 30 (n=392, 186, 204)	1.341 Liters	Standard Error 0.021
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 5 (n=401, 188, 197)	1.305 Liters	Standard Error 0.02
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 15 (n=394, 183, 200)	1.323 Liters	Standard Error 0.0208
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 30 (n=402, 189, 202)	1.319 Liters	Standard Error 0.0209
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 1 (n=404, 190, 201)	1.325 Liters	Standard Error 0.0205
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 2 (n=402, 186, 202)	1.363 Liters	Standard Error 0.0224
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 3 (n=400, 186, 199)	1.344 Liters	Standard Error 0.0215
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 4 (n=397, 184, 199)	1.346 Liters	Standard Error 0.0222
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, minute 15 (n=388, 183, 198)	1.303 Liters	Standard Error 0.0215
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, minute 45 (n=395, 185, 199)	1.320 Liters	Standard Error 0.021
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 5 (n=495, 255, 253)	1.357 Liters	Standard Error 0.0081
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 30 (n=507, 252, 254)	1.357 Liters	Standard Error 0.0126
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 2 (n=513, 253, 252)	1.397 Liters	Standard Error 0.0113
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 3 (n=510, 248, 252)	1.389 Liters	Standard Error 0.0111
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 4 (n=504, 239, 250)	1.396 Liters	Standard Error 0.0121
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 15 (n=481, 243, 239)	1.364 Liters	Standard Error 0.0115
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 15 (n=459, 220, 225)	1.376 Liters	Standard Error 0.0164
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 30 (n=460, 220, 226)	1.378 Liters	Standard Error 0.0158
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 3 (n=444, 204, 225)	1.414 Liters	Standard Error 0.0186
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 45 (n=426, 195, 205)	1.413 Liters	Standard Error 0.019
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 15 (n=428, 209, 219)	1.372 Liters	Standard Error 0.0189
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 30 (n=424, 206, 213)	1.341 Liters	Standard Error 0.0196
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 5 (n=408, 194, 212)	1.338 Liters	Standard Error 0.021
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 30 (n=410, 196, 215)	1.331 Liters	Standard Error 0.0214
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, hour 1 (n=412, 195, 215)	1.331 Liters	Standard Error 0.0213
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 1 (n=404, 190, 201)	1.482 Liters	Standard Error 0.0198
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 15 (n=430, 207, 220)	1.495 Liters	Standard Error 0.0196
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 45 (n=426, 195, 205)	1.472 Liters	Standard Error 0.0187
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 2 (n=402, 186, 202)	1.511 Liters	Standard Error 0.0214
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 5 (n=430, 206, 218)	1.464 Liters	Standard Error 0.0192
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 5 (n=429, 207, 218)	1.487 Liters	Standard Error 0.0181
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 3 (n=400, 186, 199)	1.509 Liters	Standard Error 0.0207
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 30 (n=433, 209, 220)	1.505 Liters	Standard Error 0.019
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 15 (n=479, 222, 234)	1.508 Liters	Standard Error 0.0157
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 4 (n=397, 184, 199)	1.501 Liters	Standard Error 0.0213
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 15 (n=430, 200, 214)	1.457 Liters	Standard Error 0.0177
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 30 (n=410, 196, 215)	1.444 Liters	Standard Error 0.0206
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 4 (n=437, 202, 224)	1.534 Liters	Standard Error 0.0183
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 15 (n=428, 209, 219)	1.491 Liters	Standard Error 0.0186
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, minute 45 (n=395, 185, 199)	1.411 Liters	Standard Error 0.0201
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 2 (n=446, 207, 225)	1.558 Liters	Standard Error 0.0178
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 5 (n=476, 221, 231)	1.488 Liters	Standard Error 0.0157
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 15 (n=502, 255, 254)	1.437 Liters	Standard Error 0.009
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 1 (n=455, 210, 227)	1.528 Liters	Standard Error 0.0171
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, hour 1 (n=501, 229, 240)	1.525 Liters	Standard Error 0.015
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 30 (n=507, 252, 254)	1.468 Liters	Standard Error 0.0125
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 15 (n=481, 243, 239)	1.457 Liters	Standard Error 0.0115
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 2 (n=513, 253, 252)	1.549 Liters	Standard Error 0.0112
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 30 (n=455, 212, 226)	1.491 Liters	Standard Error 0.017
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 2 (n=420, 203, 208)	1.524 Liters	Standard Error 0.021
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 3 (n=510, 248, 252)	1.560 Liters	Standard Error 0.0109
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 15 (n=448, 205, 222)	1.501 Liters	Standard Error 0.0166
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 4 (n=416, 203, 208)	1.504 Liters	Standard Error 0.0208
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 4 (n=504, 239, 250)	1.549 Liters	Standard Error 0.0117
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 5 (n=453, 212, 230)	1.477 Liters	Standard Error 0.0167
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 30 (n=503, 233, 242)	1.504 Liters	Standard Error 0.015
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 45 (n=474, 239, 232)	1.473 Liters	Standard Error 0.0118
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 15 (n=407, 191, 214)	1.443 Liters	Standard Error 0.0206
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, hour 1 (n=412, 195, 215)	1.464 Liters	Standard Error 0.0205
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 5 (n=408, 194, 212)	1.422 Liters	Standard Error 0.0202
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 5 (n=498, 223, 243)	1.472 Liters	Standard Error 0.0151
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 5 (n=398, 189, 199)	1.459 Liters	Standard Error 0.0213
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 15 (n=405, 187, 202)	1.415 Liters	Standard Error 0.0212
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 15 (n=459, 220, 225)	1.515 Liters	Standard Error 0.0163
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 15 (n=405, 188, 201)	1.477 Liters	Standard Error 0.0211
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 3 (n=416, 204, 213)	1.526 Liters	Standard Error 0.0211
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 5 (n=454, 217, 227)	1.499 Liters	Standard Error 0.0157
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 30 (n=405, 189, 201)	1.496 Liters	Standard Error 0.0222
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 1 (n=425, 206, 212)	1.487 Liters	Standard Error 0.019
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 45 (n=401, 185, 198)	1.426 Liters	Standard Error 0.0215
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 5 (n=386, 185, 199)	1.429 Liters	Standard Error 0.019
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 30 (n=424, 206, 213)	1.451 Liters	Standard Error 0.0193
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 15 (n=487, 229, 239)	1.514 Liters	Standard Error 0.0151
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 15 (n=391, 187, 203)	1.462 Liters	Standard Error 0.0192
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 15 (n=414, 200, 207)	1.458 Liters	Standard Error 0.0191
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 30 (n=460, 220, 226)	1.531 Liters	Standard Error 0.0157
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 30 (n=392, 186, 204)	1.475 Liters	Standard Error 0.02
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 30 (n=480, 223, 234)	1.525 Liters	Standard Error 0.016
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 5 (n=401, 188, 197)	1.419 Liters	Standard Error 0.0195
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 5 (421, 202, 213)	1.429 Liters	Standard Error 0.0185
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, minute 15 (n=388, 183, 198)	1.397 Liters	Standard Error 0.0205
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 15 (n=394, 183, 200)	1.451 Liters	Standard Error 0.0198
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 5 (n=495, 255, 253)	1.402 Liters	Standard Error 0.0081
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 3 (n=444, 204, 225)	1.561 Liters	Standard Error 0.0177
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 30 (n=402, 189, 202)	1.451 Liters	Standard Error 0.0202
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 30 (n=431, 207, 221)	1.498 Liters	Standard Error 0.0195
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 1 (n=511, 256, 254)	1.484 Liters	Standard Error 0.0101

Secondary

Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 12 Hours Post-dose at Day 1 and Weeks 12 and 52

FEV1 was measured with spirometry conducted according to internationally accepted standards. Measurements were made at 5, 15, and 30 minutes; and 1, 2, 3, 4, 6, 8 10, and 12 hours post-dose. Standardized FEV1 AUC was calculated by the trapezoidal rule. The analysis included the same covariates as the primary Outcome Measure.

Time frame: From 5 minutes to 12 hours post-dose at Day 1 and Weeks 12 and 52

Population: Full Analysis Set (FAS), serial spirometry subgroup: A subgroup of approximately one third of all randomized patients who received at least 1 dose of study medication.

Arm	Measure	Group	Value (LEAST_SQUARES_MEAN)	Dispersion
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 12 Hours Post-dose at Day 1 and Weeks 12 and 52	Week 12 (n=133, 69, 70)	1.539 Liters	Standard Error 0.0261
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 12 Hours Post-dose at Day 1 and Weeks 12 and 52	Week 52 (n=125, 62, 58)	1.492 Liters	Standard Error 0.0265
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 12 Hours Post-dose at Day 1 and Weeks 12 and 52	Day 1	1.566 Liters	Standard Error 0.0168
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 12 Hours Post-dose at Day 1 and Weeks 12 and 52	Week 12 (n=133, 69, 70)	1.398 Liters	Standard Error 0.0324
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 12 Hours Post-dose at Day 1 and Weeks 12 and 52	Week 52 (n=125, 62, 58)	1.364 Liters	Standard Error 0.0352
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 12 Hours Post-dose at Day 1 and Weeks 12 and 52	Day 1	1.407 Liters	Standard Error 0.0207
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 12 Hours Post-dose at Day 1 and Weeks 12 and 52	Week 52 (n=125, 62, 58)	1.424 Liters	Standard Error 0.0344
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 12 Hours Post-dose at Day 1 and Weeks 12 and 52	Week 12 (n=133, 69, 70)	1.505 Liters	Standard Error 0.032
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 12 Hours Post-dose at Day 1 and Weeks 12 and 52	Day 1	1.534 Liters	Standard Error 0.0206

Secondary

Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 23 Hours 45 Minutes and From 12 Hours to 23 Hours 45 Minutes Post-dose at Weeks 12 and 52

FEV1 was measured with spirometry conducted according to internationally accepted standards. Measurements were made at 5, 15, and 30 minutes; 1, 2, 3, 4, 6, 8, 10, and 12 hours; 23 hours 15 minutes; and 23 hours 45 minutes post-dose. Standardized FEV1 AUC was calculated by the trapezoidal rule. The analysis included the same covariates as the primary Outcome Measure.

Time frame: From 5 minutes to 23 hours 45 minutes post-dose at Weeks 12 and 52

Population: Full Analysis Set (FAS), serial spirometry subgroup: A subgroup of approximately one third of all randomized patients who received at least 1 dose of study medication.

Arm	Measure	Group	Value (LEAST_SQUARES_MEAN)	Dispersion
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 23 Hours 45 Minutes and From 12 Hours to 23 Hours 45 Minutes Post-dose at Weeks 12 and 52	Week 12	1.486 Liters	Standard Error 0.0236
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 23 Hours 45 Minutes and From 12 Hours to 23 Hours 45 Minutes Post-dose at Weeks 12 and 52	Week 52 (n=125, 62, 58)	1.445 Liters	Standard Error 0.0261
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 23 Hours 45 Minutes and From 12 Hours to 23 Hours 45 Minutes Post-dose at Weeks 12 and 52	Week 12	1.380 Liters	Standard Error 0.0298
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 23 Hours 45 Minutes and From 12 Hours to 23 Hours 45 Minutes Post-dose at Weeks 12 and 52	Week 52 (n=125, 62, 58)	1.339 Liters	Standard Error 0.0346
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 23 Hours 45 Minutes and From 12 Hours to 23 Hours 45 Minutes Post-dose at Weeks 12 and 52	Week 12	1.459 Liters	Standard Error 0.0294
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 23 Hours 45 Minutes and From 12 Hours to 23 Hours 45 Minutes Post-dose at Weeks 12 and 52	Week 52 (n=125, 62, 58)	1.379 Liters	Standard Error 0.0338

Secondary

Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 4 Hours Post-dose at Day 1 and Weeks 12, 26, and 52

FEV1 was measured with spirometry conducted according to internationally accepted standards. Measurements were made at 5, 15, and 30 minutes; and 1, 2, 3, and 4 hours post-dose. Standardized FEV1 AUC was calculated by the trapezoidal rule. The analysis included the same covariates as the primary Outcome Measure.

Time frame: From 5 minutes to 4 hours post-dose at Day 1 and Weeks 12, 26, and 52

Population: Full Analysis Set (FAS): All randomized patients who received at least 1 dose of study medication.

Arm	Measure	Group	Value (LEAST_SQUARES_MEAN)	Dispersion
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 4 Hours Post-dose at Day 1 and Weeks 12, 26, and 52	Week 52 (n=405, 192, 203)	1.502 Liters	Standard Error 0.0162
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 4 Hours Post-dose at Day 1 and Weeks 12, 26, and 52	Week 26 (n=430, 206, 216)	1.546 Liters	Standard Error 0.016
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 4 Hours Post-dose at Day 1 and Weeks 12, 26, and 52	Week 12 (n=460, 214, 232)	1.560 Liters	Standard Error 0.0134
Glycopyrronium Bromide 50 μg	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 4 Hours Post-dose at Day 1 and Weeks 12, 26, and 52	Day 1	1.570 Liters	Standard Error 0.0075
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 4 Hours Post-dose at Day 1 and Weeks 12, 26, and 52	Week 12 (n=460, 214, 232)	1.384 Liters	Standard Error 0.017
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 4 Hours Post-dose at Day 1 and Weeks 12, 26, and 52	Day 1	1.373 Liters	Standard Error 0.0092
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 4 Hours Post-dose at Day 1 and Weeks 12, 26, and 52	Week 26 (n=430, 206, 216)	1.369 Liters	Standard Error 0.0194
Placebo to Glycopyrronium Bromide	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 4 Hours Post-dose at Day 1 and Weeks 12, 26, and 52	Week 52 (n=405, 192, 203)	1.336 Liters	Standard Error 0.0203
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 4 Hours Post-dose at Day 1 and Weeks 12, 26, and 52	Week 26 (n=430, 206, 216)	1.495 Liters	Standard Error 0.019
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 4 Hours Post-dose at Day 1 and Weeks 12, 26, and 52	Day 1	1.514 Liters	Standard Error 0.0092
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 4 Hours Post-dose at Day 1 and Weeks 12, 26, and 52	Week 12 (n=460, 214, 232)	1.531 Liters	Standard Error 0.0164
Tiotropium 18 μg	Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 4 Hours Post-dose at Day 1 and Weeks 12, 26, and 52	Week 52 (n=405, 192, 203)	1.487 Liters	Standard Error 0.0196

Secondary

Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52

Just prior to FVC measurement, patients performed normal tidal breathing. The patient was given a few breaths warning before being told At the end of the next normal breath out, take a deep breath all the way in; they were then verbally encouraged to make a maximal effort before relaxing. The analysis included the same covariates as the primary Outcome Measure. Data was not collected at all time points for all Days and Weeks.

Time frame: 5, 15, and 30 minutes; 1, 2, 3, 4, 6, 8, 10, and 12 hours; 23 hours 15 minutes; and 23 hours 45 minutes post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52

Population: Full Analysis Set (FAS), serial spirometry subgroup: A subgroup of approximately one third of all randomized patients who received at least 1 dose of study medication.

Arm	Measure	Group	Value (LEAST_SQUARES_MEAN)	Dispersion
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 15 (n=124, 65, 63)	3.112 Liters	Standard Error 0.0545
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 30 (n=125, 64, 64)	3.054 Liters	Standard Error 0.0464
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 2 (n=124, 64, 63)	3.110 Liters	Standard Error 0.0516
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 3 (n=124, 64, 64)	3.210 Liters	Standard Error 0.0648
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 30 (n=125, 62, 62)	3.081 Liters	Standard Error 0.0555
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 15 (n=123, 61, 58)	3.022 Liters	Standard Error 0.0539
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 5 (n=120, 60, 57)	3.022 Liters	Standard Error 0.0596
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 15 (n=123, 60, 57)	3.042 Liters	Standard Error 0.0592
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 30 (n=125, 62, 58)	2.939 Liters	Standard Error 0.0499
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 1 (n=125, 62, 57)	3.031 Liters	Standard Error 0.0564
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 2 (n=124, 61, 58)	3.062 Liters	Standard Error 0.0556
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 6 (n=118, 59, 54)	2.986 Liters	Standard Error 0.0614
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 10 (n=119, 59, 55)	3.000 Liters	Standard Error 0.0701
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 12 (n=120, 58, 52)	2.881 Liters	Standard Error 0.0631
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 16 (n=117, 53, 46)	2.857 Liters	Standard Error 0.0694
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 5 (n=135, 74, 74)	3.027 Liters	Standard Error 0.0304
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 15 (n=139, 75, 74)	3.050 Liters	Standard Error 0.0335
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 12 (n=130, 69, 70)	3.030 Liters	Standard Error 0.0444
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 15 (n=136, 67, 70)	3.165 Liters	Standard Error 0.0501
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 30 (n=135, 67, 70)	3.248 Liters	Standard Error 0.054
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 5 (n=128, 66, 70)	3.195 Liters	Standard Error 0.0543
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 30 (n=130, 67, 71)	3.231 Liters	Standard Error 0.0567
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 5 (n=130, 69, 70)	3.060 Liters	Standard Error 0.0492
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 15 (n=129, 67, 66)	3.081 Liters	Standard Error 0.0482
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 1 (n=132, 67, 69)	3.164 Liters	Standard Error 0.0543
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 2 (n=129, 65, 68)	3.190 Liters	Standard Error 0.0526
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 3 (n=126, 64, 69)	3.240 Liters	Standard Error 0.0569
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 6 (n=123, 63, 69)	3.158 Liters	Standard Error 0.0594
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 10 (n=124, 61, 69)	3.130 Liters	Standard Error 0.0581
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 30 (n=125, 65, 63)	3.157 Liters	Standard Error 0.0559
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 5 (n=123, 62, 64)	2.994 Liters	Standard Error 0.0528
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 15 (n=121, 61, 61)	3.041 Liters	Standard Error 0.0513
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 1 (n=127, 64, 64)	3.077 Liters	Standard Error 0.052
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 4 (n=124, 64, 62)	3.111 Liters	Standard Error 0.0551
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 15 (n=120, 55, 61)	3.056 Liters	Standard Error 0.06
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 45 (n=117, 56, 61)	2.998 Liters	Standard Error 0.0512
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 5 (n=125, 62, 63)	3.023 Liters	Standard Error 0.0573
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 15 (n=123, 62, 63)	3.016 Liters	Standard Error 0.0553
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, hour 1 (n=125, 62, 63)	3.072 Liters	Standard Error 0.0564
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 5 (n=119, 61, 58)	3.033 Liters	Standard Error 0.0583
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 30 (n=123, 61, 58)	3.057 Liters	Standard Error 0.0565
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 30 (n=123, 60, 58)	3.094 Liters	Standard Error 0.0613
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 5 (n=124, 60, 57)	2.940 Liters	Standard Error 0.0551
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 15 (n=122, 59, 58)	2.960 Liters	Standard Error 0.0518
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 3 (n=123, 62, 56)	3.108 Liters	Standard Error 0.0648
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 4 (n=121, 60, 55)	3.021 Liters	Standard Error 0.0585
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 8 (n=119, 59, 54)	2.961 Liters	Standard Error 0.0646
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 22 (n=118, 60, 52)	2.812 Liters	Standard Error 0.067
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, 15 minutes (n=121, 62, 57)	2.888 Liters	Standard Error 0.0595
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, 45 minutes (n=122, 61, 57)	2.855 Liters	Standard Error 0.0558
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 30 (n=143, 77, 74)	3.055 Liters	Standard Error 0.0343
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 1 (n=144, 76, 75)	3.148 Liters	Standard Error 0.0377
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 2 (n=144, 75, 75)	3.179 Liters	Standard Error 0.0373
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 3 (n=143, 74, 73)	3.190 Liters	Standard Error 0.0433
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 4 (n=144, 70, 74)	3.138 Liters	Standard Error 0.0414
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 6 (n=142, 71, 74)	3.173 Liters	Standard Error 0.0419
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 8 (n=137, 70, 75)	3.071 Liters	Standard Error 0.0404
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day1, hour 10 (n=134, 72, 75)	3.134 Liters	Standard Error 0.0414
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 15 (n=129, 71, 72)	2.991 Liters	Standard Error 0.0385
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 45 (n=128, 74, 75)	3.014 Liters	Standard Error 0.0364
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 5 (n=135, 65, 73)	3.051 Liters	Standard Error 0.0439
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 15 (n=133, 70, 72)	3.103 Liters	Standard Error 0.0443
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 30 (n= 139, 70, 74)	3.134 Liters	Standard Error 0.042
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, hour 1 (n=140, 68, 74)	3.152 Liters	Standard Error 0.0434
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 5 (n=134, 66, 68)	3.139 Liters	Standard Error 0.043
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 15 (n=130, 66, 71)	3.167 Liters	Standard Error 0.0507
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 30 (n=133, 69, 67)	3.058 Liters	Standard Error 0.0479
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 4 (n=124, 64, 68)	3.119 Liters	Standard Error 0.0576
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 8 (n=121, 64, 69)	3.083 Liters	Standard Error 0.0534
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 12 (n=122, 58, 68)	3.072 Liters	Standard Error 0.0599
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 16 (n=109, 56, 57)	2.933 Liters	Standard Error 0.0645
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 22 (n=117, 60, 63)	2.924 Liters	Standard Error 0.0517
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 15 (n=126, 66, 67)	3.091 Liters	Standard Error 0.0548
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 45 (n=124, 65, 63)	3.055 Liters	Standard Error 0.0507
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 5 (n=123, 65, 64)	3.156 Liters	Standard Error 0.0608
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 15 (n=124, 65, 65)	3.156 Liters	Standard Error 0.0576
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 30 (n=125, 65, 65)	3.198 Liters	Standard Error 0.0552
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 5 (n=125, 66, 63)	3.093 Liters	Standard Error 0.0526
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 5 (n=125, 66, 63)	2.781 Liters	Standard Error 0.063
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 1 (n=144, 76, 75)	2.791 Liters	Standard Error 0.046
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 30 (n=125, 64, 64)	2.700 Liters	Standard Error 0.0597
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 15 (n=123, 62, 63)	2.731 Liters	Standard Error 0.0691
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 1 (n=127, 64, 64)	2.678 Liters	Standard Error 0.0658
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 30 (n=125, 65, 65)	2.815 Liters	Standard Error 0.0676
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 15 (n=126, 66, 67)	2.862 Liters	Standard Error 0.0676
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 2 (n=124, 64, 63)	2.771 Liters	Standard Error 0.0655
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 30 (n=125, 65, 63)	2.778 Liters	Standard Error 0.0677
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 6 (n=123, 63, 69)	2.852 Liters	Standard Error 0.0731
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 15 (n=130, 66, 71)	2.823 Liters	Standard Error 0.0615
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 15 (n=120, 55, 61)	2.803 Liters	Standard Error 0.0749
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 45 (n=117, 56, 61)	2.752 Liters	Standard Error 0.0667
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 15 (n=133, 70, 72)	2.790 Liters	Standard Error 0.0536
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 2 (n=144, 75, 75)	2.802 Liters	Standard Error 0.046
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 30 (n=125, 62, 62)	2.687 Liters	Standard Error 0.0715
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, hour 1 (n=125, 62, 63)	2.703 Liters	Standard Error 0.0707
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 5 (n=123, 62, 64)	2.700 Liters	Standard Error 0.067
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 5 (n=119, 61, 58)	2.716 Liters	Standard Error 0.0744
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 15 (n=123, 60, 57)	2.702 Liters	Standard Error 0.0726
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 8 (n=121, 64, 69)	2.760 Liters	Standard Error 0.0657
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 15 (n=123, 61, 58)	2.695 Liters	Standard Error 0.0706
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 45 (n=128, 74, 75)	2.817 Liters	Standard Error 0.0444
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 30 (n=123, 61, 58)	2.723 Liters	Standard Error 0.0734
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 15 (n=124, 65, 65)	2.801 Liters	Standard Error 0.0695
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 5 (n=120, 60, 57)	2.731 Liters	Standard Error 0.0727
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 3 (n=143, 74, 73)	2.826 Liters	Standard Error 0.0526
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 30 (n=123, 60, 58)	2.731 Liters	Standard Error 0.0749
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 15 (n=121, 61, 61)	2.692 Liters	Standard Error 0.0652
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 5 (n=124, 60, 57)	2.645 Liters	Standard Error 0.0701
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 5 (n=135, 65, 73)	2.793 Liters	Standard Error 0.0553
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 1 (n=132, 67, 69)	2.737 Liters	Standard Error 0.0663
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 4 (n=144, 70, 74)	2.783 Liters	Standard Error 0.0515
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 2 (n=124, 61, 58)	2.714 Liters	Standard Error 0.0689
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 15 (n=122, 59, 58)	2.640 Liters	Standard Error 0.0675
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 4 (n=121, 60, 55)	2.694 Liters	Standard Error 0.0724
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 30 (n=125, 62, 58)	2.625 Liters	Standard Error 0.065
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 1 (n=125, 62, 57)	2.617 Liters	Standard Error 0.0698
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 6 (n=118, 59, 54)	2.690 Liters	Standard Error 0.077
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 3 (n=124, 64, 64)	2.871 Liters	Standard Error 0.0765
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 8 (n=119, 59, 54)	2.637 Liters	Standard Error 0.0793
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 10 (n=124, 61, 69)	2.860 Liters	Standard Error 0.0722
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 16 (n=109, 56, 57)	2.701 Liters	Standard Error 0.08
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 10 (n=119, 59, 55)	2.687 Liters	Standard Error 0.084
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 3 (n=123, 62, 56)	2.716 Liters	Standard Error 0.0766
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 6 (n=142, 71, 74)	2.846 Liters	Standard Error 0.0514
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 12 (n=120, 58, 52)	2.636 Liters	Standard Error 0.0831
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 4 (n=124, 64, 62)	2.791 Liters	Standard Error 0.0664
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 22 (n=118, 60, 52)	2.604 Liters	Standard Error 0.081
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, 15 minutes (n=121, 62, 57)	2.678 Liters	Standard Error 0.0751
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 2 (n=129, 65, 68)	2.784 Liters	Standard Error 0.0664
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 3 (n=126, 64, 69)	2.864 Liters	Standard Error 0.0713
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 12 (n=122, 58, 68)	2.771 Liters	Standard Error 0.077
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 8 (n=137, 70, 75)	2.804 Liters	Standard Error 0.0506
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 15 (n=139, 75, 74)	2.802 Liters	Standard Error 0.0403
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 16 (n=117, 53, 46)	2.542 Liters	Standard Error 0.0857
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 30 (n=133, 69, 67)	2.696 Liters	Standard Error 0.0585
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 12 (n=130, 69, 70)	2.709 Liters	Standard Error 0.0535
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 15 (n=129, 67, 66)	2.740 Liters	Standard Error 0.0588
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 5 (n=123, 65, 64)	2.864 Liters	Standard Error 0.0719
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 30 (n= 139, 70, 74)	2.825 Liters	Standard Error 0.0519
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, hour 1 (n=140, 68, 74)	2.770 Liters	Standard Error 0.0537
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 45 (n=124, 65, 63)	2.826 Liters	Standard Error 0.063
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 15 (n=136, 67, 70)	2.850 Liters	Standard Error 0.0611
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 5 (n=125, 62, 63)	2.731 Liters	Standard Error 0.0715
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day1, hour 10 (n=134, 72, 75)	2.865 Liters	Standard Error 0.0514
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 30 (n=135, 67, 70)	2.884 Liters	Standard Error 0.0644
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 4 (n=124, 64, 68)	2.745 Liters	Standard Error 0.0714
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, 45 minutes (n=122, 61, 57)	2.607 Liters	Standard Error 0.07
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 5 (n=128, 66, 70)	2.826 Liters	Standard Error 0.0644
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 5 (n=135, 74, 74)	2.826 Liters	Standard Error 0.0363
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 15 (n=124, 65, 63)	2.770 Liters	Standard Error 0.0655
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 30 (n=130, 67, 71)	2.821 Liters	Standard Error 0.0675
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 30 (n=143, 77, 74)	2.752 Liters	Standard Error 0.0416
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 22 (n=117, 60, 63)	2.673 Liters	Standard Error 0.0647
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 5 (n=130, 69, 70)	2.728 Liters	Standard Error 0.0596
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 5 (n=134, 66, 68)	2.866 Liters	Standard Error 0.0551
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 15 (n=129, 71, 72)	2.800 Liters	Standard Error 0.0478
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 45 (n=128, 74, 75)	2.994 Liters	Standard Error 0.0442
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 15 (n=129, 67, 66)	3.018 Liters	Standard Error 0.0593
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 30 (n=133, 69, 67)	3.027 Liters	Standard Error 0.0591
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 15 (n=129, 71, 72)	2.988 Liters	Standard Error 0.0471
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 22 (n=117, 60, 63)	2.870 Liters	Standard Error 0.0629
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 2 (n=129, 65, 68)	3.155 Liters	Standard Error 0.0649
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 4 (n=124, 64, 68)	3.084 Liters	Standard Error 0.0686
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 8 (n=121, 64, 69)	3.011 Liters	Standard Error 0.0644
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 12 (n=122, 58, 68)	3.020 Liters	Standard Error 0.0722
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 15 (n=124, 65, 63)	3.029 Liters	Standard Error 0.0666
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 30 (n=125, 65, 63)	3.050 Liters	Standard Error 0.0688
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 5 (n=123, 62, 64)	2.954 Liters	Standard Error 0.0658
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 15 (n=133, 70, 72)	3.103 Liters	Standard Error 0.0536
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 15 (n=126, 66, 67)	3.110 Liters	Standard Error 0.0671
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 30 (n= 139, 70, 74)	3.078 Liters	Standard Error 0.0513
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 4 (n=124, 64, 62)	3.086 Liters	Standard Error 0.0664
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 30 (n=125, 65, 65)	3.112 Liters	Standard Error 0.0679
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 15 (n=120, 55, 61)	2.932 Liters	Standard Error 0.0721
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 5 (n=125, 62, 63)	2.881 Liters	Standard Error 0.0706
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 15 (n=123, 62, 63)	2.898 Liters	Standard Error 0.0683
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 30 (n=125, 62, 62)	2.971 Liters	Standard Error 0.0708
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 5 (n=134, 66, 68)	3.071 Liters	Standard Error 0.0534
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 45 (n=124, 65, 63)	3.004 Liters	Standard Error 0.0638
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 30 (n=123, 61, 58)	3.098 Liters	Standard Error 0.0734
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 5 (n=120, 60, 57)	2.963 Liters	Standard Error 0.0726
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 15 (n=123, 60, 57)	2.937 Liters	Standard Error 0.0725
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 15 (n=130, 66, 71)	3.101 Liters	Standard Error 0.0603
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 15 (n=121, 61, 61)	2.976 Liters	Standard Error 0.0644
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 5 (n=124, 60, 57)	2.860 Liters	Standard Error 0.0702
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 1 (n=125, 62, 57)	2.980 Liters	Standard Error 0.0704
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 1 (n=132, 67, 69)	3.098 Liters	Standard Error 0.0655
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 3 (n=123, 62, 56)	3.053 Liters	Standard Error 0.0779
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 12 (n=120, 58, 52)	2.849 Liters	Standard Error 0.0847
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 16 (n=117, 53, 46)	2.772 Liters	Standard Error 0.0873
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 3 (n=126, 64, 69)	3.146 Liters	Standard Error 0.0685
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 22 (n=118, 60, 52)	2.716 Liters	Standard Error 0.0827
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 5 (n=123, 65, 64)	3.104 Liters	Standard Error 0.0723
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, 15 minutes (n=121, 62, 57)	2.852 Liters	Standard Error 0.0755
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 6 (n=123, 63, 69)	3.120 Liters	Standard Error 0.07
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 30 (n=143, 77, 74)	2.979 Liters	Standard Error 0.0422
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 30 (n=125, 64, 64)	2.994 Liters	Standard Error 0.0589
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 1 (n=127, 64, 64)	3.016 Liters	Standard Error 0.0651
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 1 (n=144, 76, 75)	3.041 Liters	Standard Error 0.0463
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 2 (n=124, 64, 63)	3.080 Liters	Standard Error 0.065
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 10 (n=124, 61, 69)	3.117 Liters	Standard Error 0.0692
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 3 (n=124, 64, 64)	3.176 Liters	Standard Error 0.0762
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 45 (n=117, 56, 61)	2.895 Liters	Standard Error 0.0646
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, hour 1 (n=125, 62, 63)	2.963 Liters	Standard Error 0.0699
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 5 (n=119, 61, 58)	3.069 Liters	Standard Error 0.0746
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 2 (n=144, 75, 75)	3.049 Liters	Standard Error 0.0461
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 15 (n=123, 61, 58)	3.065 Liters	Standard Error 0.0699
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 30 (n=123, 60, 58)	2.985 Liters	Standard Error 0.0747
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 15 (n=122, 59, 58)	2.935 Liters	Standard Error 0.0666
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 3 (n=143, 74, 73)	3.119 Liters	Standard Error 0.0531
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 30 (n=125, 62, 58)	2.929 Liters	Standard Error 0.0652
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 15 (n=124, 65, 65)	3.082 Liters	Standard Error 0.0699
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 2 (n=124, 61, 58)	3.021 Liters	Standard Error 0.0689
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 4 (n=121, 60, 55)	2.978 Liters	Standard Error 0.0735
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 4 (n=144, 70, 74)	3.102 Liters	Standard Error 0.0512
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 6 (n=118, 59, 54)	2.982 Liters	Standard Error 0.0781
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 8 (n=119, 59, 54)	2.942 Liters	Standard Error 0.0805
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 10 (n=119, 59, 55)	3.012 Liters	Standard Error 0.0844
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 6 (n=142, 71, 74)	3.148 Liters	Standard Error 0.0513
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, 45 minutes (n=122, 61, 57)	2.797 Liters	Standard Error 0.0702
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 16 (n=109, 56, 57)	2.880 Liters	Standard Error 0.0785
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 5 (n=135, 74, 74)	2.956 Liters	Standard Error 0.0363
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 15 (n=139, 75, 74)	2.991 Liters	Standard Error 0.0406
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 8 (n=137, 70, 75)	3.074 Liters	Standard Error 0.0498
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 5 (n=135, 65, 73)	3.014 Liters	Standard Error 0.0534
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, hour 1 (n=140, 68, 74)	3.060 Liters	Standard Error 0.0528
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 5 (n=125, 66, 63)	2.993 Liters	Standard Error 0.0643
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 15 (n=136, 67, 70)	3.092 Liters	Standard Error 0.0602
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 30 (n=135, 67, 70)	3.180 Liters	Standard Error 0.0636
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day1, hour 10 (n=134, 72, 75)	3.119 Liters	Standard Error 0.051
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 5 (n=128, 66, 70)	3.097 Liters	Standard Error 0.0632
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 12 (n=130, 69, 70)	3.012 Liters	Standard Error 0.0537
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 30 (n=130, 67, 71)	3.149 Liters	Standard Error 0.0664
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 5 (n=130, 69, 70)	3.023 Liters	Standard Error 0.0596

Secondary

Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52

Time frame: 5, 15, and 30 minutes; and 1, 2, 3, 4 hours post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52

Population: Full Analysis Set (FAS): All randomized patients who received at least 1 dose of study medication.

Arm	Measure	Group	Value (LEAST_SQUARES_MEAN)	Dispersion
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 1 (n=455, 210, 227)	3.062 Liters	Standard Error 0.0267
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 5 (n=401, 188, 197)	2.899 Liters	Standard Error 0.0309
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 45 (n=401, 185, 198)	2.952 Liters	Standard Error 0.0305
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 2 (n=446, 207, 225)	3.093 Liters	Standard Error 0.0266
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 45 (n=474, 239, 232)	2.930 Liters	Standard Error 0.0178
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 15 (n=405, 187, 202)	2.971 Liters	Standard Error 0.0321
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 3 (n=444, 204, 225)	3.129 Liters	Standard Error 0.0275
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 4 (n=437, 202, 224)	3.050 Liters	Standard Error 0.0278
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 1 (n=511, 256, 254)	3.074 Liters	Standard Error 0.0173
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 4 (n=416, 203, 208)	3.022 Liters	Standard Error 0.0312
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 15 (n=430, 200, 214)	2.991 Liters	Standard Error 0.0282
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 3 (n=416, 204, 213)	3.097 Liters	Standard Error 0.0331
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 45 (n=426, 195, 205)	2.977 Liters	Standard Error 0.0268
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 30 (n=480, 223, 234)	3.085 Liters	Standard Error 0.0243
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 2 (n=420, 203, 208)	3.049 Liters	Standard Error 0.0308
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 5 (n=429, 207, 218)	3.016 Liters	Standard Error 0.0301
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 5 (n=498, 223, 243)	2.984 Liters	Standard Error 0.0222
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 1 (n=425, 206, 212)	3.034 Liters	Standard Error 0.0293
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 15 (n=428, 209, 219)	3.029 Liters	Standard Error 0.0293
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 15 (n=502, 255, 254)	2.982 Liters	Standard Error 0.0164
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 30 (n=424, 206, 213)	2.983 Liters	Standard Error 0.0282
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 30 (n=433, 209, 220)	3.063 Liters	Standard Error 0.0298
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 15 (n=414, 200, 207)	2.980 Liters	Standard Error 0.0298
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 5 (n=430, 206, 218)	2.985 Liters	Standard Error 0.0286
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 15 (n=487, 229, 239)	3.016 Liters	Standard Error 0.022
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 5 (421, 202, 213)	2.956 Liters	Standard Error 0.0289
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 15 (n=430, 207, 220)	3.020 Liters	Standard Error 0.0293
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 30 (n=431, 207, 221)	3.058 Liters	Standard Error 0.0309
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 3 (n=400, 186, 199)	3.029 Liters	Standard Error 0.0359
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 5 (n=495, 255, 253)	2.915 Liters	Standard Error 0.0145
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 30 (n=503, 233, 242)	3.028 Liters	Standard Error 0.0212
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 2 (n=513, 253, 252)	3.119 Liters	Standard Error 0.0182
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 15 (n=394, 183, 200)	2.942 Liters	Standard Error 0.0314
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, hour 1 (n=501, 229, 240)	3.068 Liters	Standard Error 0.0213
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, minute 45 (n=395, 185, 199)	2.869 Liters	Standard Error 0.0342
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 30 (n=392, 186, 204)	2.999 Liters	Standard Error 0.0342
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 5 (n=476, 221, 231)	3.004 Liters	Standard Error 0.0215
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 2 (n=402, 186, 202)	2.997 Liters	Standard Error 0.0354
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 15 (n=391, 187, 203)	2.971 Liters	Standard Error 0.033
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 15 (n=479, 222, 234)	3.024 Liters	Standard Error 0.0234
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 3 (n=510, 248, 252)	3.129 Liters	Standard Error 0.0193
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 5 (n=386, 185, 199)	2.925 Liters	Standard Error 0.0328
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, minute 15 (n=388, 183, 198)	2.866 Liters	Standard Error 0.0349
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 30 (n=405, 189, 201)	3.016 Liters	Standard Error 0.0345
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 5 (n=454, 217, 227)	3.047 Liters	Standard Error 0.0262
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 1 (n=404, 190, 201)	2.992 Liters	Standard Error 0.0339
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 15 (n=405, 188, 201)	3.001 Liters	Standard Error 0.0336
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 15 (n=459, 220, 225)	3.050 Liters	Standard Error 0.0257
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 4 (n=504, 239, 250)	3.076 Liters	Standard Error 0.0192
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 5 (n=398, 189, 199)	2.982 Liters	Standard Error 0.0344
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 30 (n=460, 220, 226)	3.079 Liters	Standard Error 0.0265
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 30 (n=507, 252, 254)	3.004 Liters	Standard Error 0.0177
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, hour 1 (n=412, 195, 215)	3.014 Liters	Standard Error 0.0336
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 5 (n=453, 212, 230)	2.991 Liters	Standard Error 0.0253
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 30 (n=402, 189, 202)	2.923 Liters	Standard Error 0.0325
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 30 (n=410, 196, 215)	3.002 Liters	Standard Error 0.0333
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 15 (n=448, 205, 222)	3.003 Liters	Standard Error 0.0252
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 15 (n=481, 243, 239)	2.926 Liters	Standard Error 0.0178
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 15 (n=407, 191, 214)	2.983 Liters	Standard Error 0.0327
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 30 (n=455, 212, 226)	2.985 Liters	Standard Error 0.0251
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 4 (n=397, 184, 199)	2.984 Liters	Standard Error 0.0359
Glycopyrronium Bromide 50 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 5 (n=408, 194, 212)	2.967 Liters	Standard Error 0.0321
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 30 (n=405, 189, 201)	2.734 Liters	Standard Error 0.0419
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 15 (n=502, 255, 254)	2.719 Liters	Standard Error 0.0199
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 1 (n=511, 256, 254)	2.732 Liters	Standard Error 0.0214
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 2 (n=513, 253, 252)	2.762 Liters	Standard Error 0.0227
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 3 (n=510, 248, 252)	2.811 Liters	Standard Error 0.0243
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 4 (n=504, 239, 250)	2.767 Liters	Standard Error 0.0244
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 15 (n=481, 243, 239)	2.745 Liters	Standard Error 0.022
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 45 (n=474, 239, 232)	2.749 Liters	Standard Error 0.0221
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 5 (n=498, 223, 243)	2.760 Liters	Standard Error 0.0282
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 15 (n=487, 229, 239)	2.748 Liters	Standard Error 0.0274
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 30 (n=503, 233, 242)	2.756 Liters	Standard Error 0.0269
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, hour 1 (n=501, 229, 240)	2.757 Liters	Standard Error 0.0271
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 5 (n=476, 221, 231)	2.768 Liters	Standard Error 0.0277
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 15 (n=479, 222, 234)	2.771 Liters	Standard Error 0.0294
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 30 (n=480, 223, 234)	2.804 Liters	Standard Error 0.0305
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 5 (n=454, 217, 227)	2.767 Liters	Standard Error 0.0313
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 15 (n=459, 220, 225)	2.764 Liters	Standard Error 0.0312
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 30 (n=460, 220, 226)	2.768 Liters	Standard Error 0.0322
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 5 (n=453, 212, 230)	2.726 Liters	Standard Error 0.0313
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 15 (n=448, 205, 222)	2.735 Liters	Standard Error 0.0316
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 30 (n=455, 212, 226)	2.707 Liters	Standard Error 0.0314
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 1 (n=455, 210, 227)	2.741 Liters	Standard Error 0.0333
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 2 (n=446, 207, 225)	2.801 Liters	Standard Error 0.0335
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 4 (n=437, 202, 224)	2.793 Liters	Standard Error 0.0349
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 45 (n=426, 195, 205)	2.799 Liters	Standard Error 0.0336
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 5 (n=429, 207, 218)	2.753 Liters	Standard Error 0.0362
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 15 (n=428, 209, 219)	2.737 Liters	Standard Error 0.0353
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 5 (n=430, 206, 218)	2.744 Liters	Standard Error 0.0349
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 30 (n=431, 207, 221)	2.774 Liters	Standard Error 0.0374
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 5 (421, 202, 213)	2.733 Liters	Standard Error 0.0352
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 15 (n=414, 200, 207)	2.713 Liters	Standard Error 0.0363
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 30 (n=424, 206, 213)	2.715 Liters	Standard Error 0.0342
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 1 (n=425, 206, 212)	2.721 Liters	Standard Error 0.0352
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 2 (n=420, 203, 208)	2.777 Liters	Standard Error 0.037
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 3 (n=416, 204, 213)	2.831 Liters	Standard Error 0.0389
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 4 (n=416, 203, 208)	2.776 Liters	Standard Error 0.0369
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 15 (n=405, 187, 202)	2.758 Liters	Standard Error 0.0387
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 45 (n=401, 185, 198)	2.759 Liters	Standard Error 0.0373
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 5 (n=408, 194, 212)	2.713 Liters	Standard Error 0.0387
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 15 (n=407, 191, 214)	2.718 Liters	Standard Error 0.0392
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 30 (n=410, 196, 215)	2.690 Liters	Standard Error 0.04
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, hour 1 (n=412, 195, 215)	2.711 Liters	Standard Error 0.04
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 5 (n=398, 189, 199)	2.727 Liters	Standard Error 0.0415
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 15 (n=405, 188, 201)	2.713 Liters	Standard Error 0.041
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 5 (n=495, 255, 253)	2.731 Liters	Standard Error 0.0174
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 5 (n=386, 185, 199)	2.729 Liters	Standard Error 0.0393
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 15 (n=391, 187, 203)	2.729 Liters	Standard Error 0.0398
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 30 (n=392, 186, 204)	2.731 Liters	Standard Error 0.0409
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 15 (n=394, 183, 200)	2.701 Liters	Standard Error 0.0389
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 30 (n=507, 252, 254)	2.692 Liters	Standard Error 0.0219
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 3 (n=444, 204, 225)	2.839 Liters	Standard Error 0.0346
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 15 (n=430, 200, 214)	2.799 Liters	Standard Error 0.0349
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 30 (n=433, 209, 220)	2.747 Liters	Standard Error 0.0359
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 15 (n=430, 207, 220)	2.749 Liters	Standard Error 0.0356
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 5 (n=401, 188, 197)	2.673 Liters	Standard Error 0.0377
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 30 (n=402, 189, 202)	2.666 Liters	Standard Error 0.0391
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 1 (n=404, 190, 201)	2.696 Liters	Standard Error 0.0405
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 2 (n=402, 186, 202)	2.727 Liters	Standard Error 0.0421
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 3 (n=400, 186, 199)	2.742 Liters	Standard Error 0.0427
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 4 (n=397, 184, 199)	2.725 Liters	Standard Error 0.0425
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, minute 15 (n=388, 183, 198)	2.675 Liters	Standard Error 0.0419
Placebo to Glycopyrronium Bromide	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, minute 45 (n=395, 185, 199)	2.694 Liters	Standard Error 0.0406
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 5 (n=401, 188, 197)	2.916 Liters	Standard Error 0.0367
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 15 (n=407, 191, 214)	2.948 Liters	Standard Error 0.0376
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 5 (n=453, 212, 230)	2.978 Liters	Standard Error 0.0304
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 15 (n=394, 183, 200)	2.969 Liters	Standard Error 0.0371
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 30 (n=410, 196, 215)	2.947 Liters	Standard Error 0.0386
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 30 (n=460, 220, 226)	3.079 Liters	Standard Error 0.0319
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 4 (n=504, 239, 250)	3.031 Liters	Standard Error 0.0237
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, hour 1 (n=412, 195, 215)	2.959 Liters	Standard Error 0.0385
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 15 (n=459, 220, 225)	3.046 Liters	Standard Error 0.0311
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 15 (n=502, 255, 254)	2.903 Liters	Standard Error 0.0198
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 5 (n=398, 189, 199)	2.983 Liters	Standard Error 0.0406
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 9, minute 5 (n=454, 217, 227)	3.029 Liters	Standard Error 0.0309
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, minute 30 (n=402, 189, 202)	2.962 Liters	Standard Error 0.0378
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 15 (n=405, 188, 201)	3.001 Liters	Standard Error 0.0398
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 30 (n=480, 223, 234)	3.063 Liters	Standard Error 0.0297
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 3 (n=510, 248, 252)	3.073 Liters	Standard Error 0.0239
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 42, minute 30 (n=405, 189, 201)	3.021 Liters	Standard Error 0.0408
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 15 (n=479, 222, 234)	3.024 Liters	Standard Error 0.0286
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, minute 45 (n=395, 185, 199)	2.868 Liters	Standard Error 0.039
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 5, minute 5 (n=476, 221, 231)	3.011 Liters	Standard Error 0.027
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 1 (n=404, 190, 201)	3.011 Liters	Standard Error 0.0393
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 15 (n=391, 187, 203)	2.962 Liters	Standard Error 0.0384
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, hour 1 (n=501, 229, 240)	3.023 Liters	Standard Error 0.0267
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 2 (n=513, 253, 252)	3.033 Liters	Standard Error 0.0226
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 30 (n=503, 233, 242)	3.018 Liters	Standard Error 0.0265
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 23, minute 15 (n=388, 183, 198)	2.865 Liters	Standard Error 0.0402
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 15 (n=487, 229, 239)	3.030 Liters	Standard Error 0.027
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 2 (n=402, 186, 202)	3.005 Liters	Standard Error 0.0405
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 15 (n=430, 207, 220)	2.994 Liters	Standard Error 0.0345
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 15, minute 5 (n=498, 223, 243)	2.980 Liters	Standard Error 0.0272
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 30 (n=431, 207, 221)	3.028 Liters	Standard Error 0.0362
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 20, minute 5 (n=430, 206, 218)	2.966 Liters	Standard Error 0.0338
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 45 (n=474, 239, 232)	2.923 Liters	Standard Error 0.0224
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 5 (421, 202, 213)	2.945 Liters	Standard Error 0.0345
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 30 (n=433, 209, 220)	3.036 Liters	Standard Error 0.0353
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 1 (n=511, 256, 254)	2.975 Liters	Standard Error 0.0213
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 15 (n=414, 200, 207)	2.959 Liters	Standard Error 0.036
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 15 (n=428, 209, 219)	3.002 Liters	Standard Error 0.0348
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 3 (n=444, 204, 225)	3.096 Liters	Standard Error 0.0332
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, minute 30 (n=424, 206, 213)	2.949 Liters	Standard Error 0.0337
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 16, minute 5 (n=429, 207, 218)	3.009 Liters	Standard Error 0.0355
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 4 (n=397, 184, 199)	2.991 Liters	Standard Error 0.041
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 1 (n=425, 206, 212)	2.997 Liters	Standard Error 0.0346
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 45 (n=426, 195, 205)	2.946 Liters	Standard Error 0.0332
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 52, hour 3 (n=400, 186, 199)	3.020 Liters	Standard Error 0.0413
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 2 (n=420, 203, 208)	3.036 Liters	Standard Error 0.0366
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 23, minute 15 (n=430, 200, 214)	2.985 Liters	Standard Error 0.0341
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 30 (n=507, 252, 254)	2.937 Liters	Standard Error 0.0217
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 3 (n=416, 204, 213)	3.065 Liters	Standard Error 0.0381
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 4 (n=437, 202, 224)	3.054 Liters	Standard Error 0.0333
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 5 (n=386, 185, 199)	2.942 Liters	Standard Error 0.0381
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 4 (n=416, 203, 208)	3.021 Liters	Standard Error 0.0364
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 2 (n=446, 207, 225)	3.065 Liters	Standard Error 0.0324
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 50, minute 30 (n=392, 186, 204)	2.998 Liters	Standard Error 0.0394
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 15 (n=405, 187, 202)	2.901 Liters	Standard Error 0.0379
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, hour 1 (n=455, 210, 227)	3.048 Liters	Standard Error 0.0322
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, hour 23, minute 15 (n=481, 243, 239)	2.923 Liters	Standard Error 0.022
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 26, hour 23, minute 45 (n=401, 185, 198)	2.883 Liters	Standard Error 0.0368
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 30 (n=455, 212, 226)	2.987 Liters	Standard Error 0.0306
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Day 1, minute 5 (n=495, 255, 253)	2.856 Liters	Standard Error 0.0174
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 34, minute 5 (n=408, 194, 212)	2.919 Liters	Standard Error 0.0374
Tiotropium 18 μg	Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52	Week 12, minute 15 (n=448, 205, 222)	3.004 Liters	Standard Error 0.0307

Secondary

Health-related Quality of Life (QoL) Assessed With the St. George Respiratory Questionnaire (SGRQ) at Week 52

The SGRQ contained 51 patient-rated items divided into three components: Symptoms (respiratory symptoms, their frequency, and severity), Activity (activities that cause or are limited by breathlessness), and Impacts (social functioning and psychological disturbances resulting from airway disease). A total score for the 3 components was calculated and ranged from 0 to 100. Higher values indicate greater impairment of QoL. The analysis included the same covariates as the primary Outcome Measure.

Time frame: Week 52

Population: Full Analysis Set (FAS): All randomized patients who received at least 1 dose of study medication.

Arm	Measure	Value (LEAST_SQUARES_MEAN)	Dispersion
Glycopyrronium Bromide 50 μg	Health-related Quality of Life (QoL) Assessed With the St. George Respiratory Questionnaire (SGRQ) at Week 52	40.85 Units on a scale	Standard Error 0.854
Placebo to Glycopyrronium Bromide	Health-related Quality of Life (QoL) Assessed With the St. George Respiratory Questionnaire (SGRQ) at Week 52	44.16 Units on a scale	Standard Error 1.04
Tiotropium 18 μg	Health-related Quality of Life (QoL) Assessed With the St. George Respiratory Questionnaire (SGRQ) at Week 52	41.32 Units on a scale	Standard Error 1.024

Secondary

Number of Moderate or Severe Exacerbations of Chronic Obstructive Pulmonary Disease (COPD) Per Year During the Study (Baseline to Week 52)

The number of moderate or severe exacerbations of COPD per year during the study was calculated by dividing the total number of exacerbations during the study by the total number of years of treatment. A COPD exacerbation was considered to be moderate if treatment with systemic corticosteroids and/or antibiotic was required. A COPD exacerbation was considered to be severe if treatment for moderate severity and hospitalization was required.

Time frame: Baseline to Week 52

Population: Full Analysis Set (FAS): All randomized patients who received at least 1 dose of study medication.

Arm	Measure	Value (NUMBER)
Glycopyrronium Bromide 50 μg	Number of Moderate or Severe Exacerbations of Chronic Obstructive Pulmonary Disease (COPD) Per Year During the Study (Baseline to Week 52)	0.54 Exacerbations per treatment year
Placebo to Glycopyrronium Bromide	Number of Moderate or Severe Exacerbations of Chronic Obstructive Pulmonary Disease (COPD) Per Year During the Study (Baseline to Week 52)	0.80 Exacerbations per treatment year
Tiotropium 18 μg	Number of Moderate or Severe Exacerbations of Chronic Obstructive Pulmonary Disease (COPD) Per Year During the Study (Baseline to Week 52)	0.62 Exacerbations per treatment year

Secondary

Percentage of Days Able to Perform Usual Daily Activities During the Study (Baseline to Week 52)

A day able to perform usual daily activities was defined as any day where the patient recorded in their electronic diary in the evening that they were not prevented from performing their usual daily activities due to respiratory symptoms during the previous 12 hours. The percentage of days able to perform usual daily activities was calculated as the total number of days able to perform usual daily activities over the 52 week treatment period divided by the total number of days where diary recordings were made.

Time frame: Baseline to Week 52

Population: Full Analysis Set (FAS): All randomized patients who received at least 1 dose of study medication.

Arm	Measure	Value (LEAST_SQUARES_MEAN)	Dispersion
Glycopyrronium Bromide 50 μg	Percentage of Days Able to Perform Usual Daily Activities During the Study (Baseline to Week 52)	38.02 Percentage of days	Standard Error 1.883
Placebo to Glycopyrronium Bromide	Percentage of Days Able to Perform Usual Daily Activities During the Study (Baseline to Week 52)	36.18 Percentage of days	Standard Error 2.27
Tiotropium 18 μg	Percentage of Days Able to Perform Usual Daily Activities During the Study (Baseline to Week 52)	38.09 Percentage of days	Standard Error 2.259

Secondary

Percentage of Days With no Daytime Symptoms During the Study (Baseline to Week 52)

A day with no daytime symptoms was defined as any day where the patient recorded no cough, no wheeze, no production of sputum, no feeling of breathlessness (other than when running), and no puffs of rescue medication during the previous 12 hours in evening entry in the electronic patient diary. The percentage of days with no daytime symptoms was calculated as the total number of days with no daytime symptoms over the 52 week treatment period divided by the total number of days where diary recordings were made.

Time frame: Baseline to Week 52

Population: Full Analysis Set (FAS): All randomized patients who received at least 1 dose of study medication.

Arm	Measure	Value (LEAST_SQUARES_MEAN)	Dispersion
Glycopyrronium Bromide 50 μg	Percentage of Days With no Daytime Symptoms During the Study (Baseline to Week 52)	6.54 Percentage of days	Standard Error 1.208
Placebo to Glycopyrronium Bromide	Percentage of Days With no Daytime Symptoms During the Study (Baseline to Week 52)	3.81 Percentage of days	Standard Error 1.431
Tiotropium 18 μg	Percentage of Days With no Daytime Symptoms During the Study (Baseline to Week 52)	7.14 Percentage of days	Standard Error 1.424

Secondary

Percentage of Nights With no Nighttime Awakenings During the Study (Baseline to Week 52)

A night with no nighttime awakenings was defined as any night where the patient did not wake up due to 1 or more of 6 symptoms (respiratory symptoms, cough, wheeze, amount of sputum, color of sputum, and breathlessness). Symptoms occurring during the previous 12 hours were recorded each morning and evening by the patient in an electronic diary. The percentage of nights with 'no nighttime awakenings' was calculated as the total number of nights with no nighttime awakenings over the 52 week treatment period divided by the total number of nights where diary recordings were made.

Time frame: Baseline to Week 52

Population: Full Analysis Set (FAS): All randomized patients who received at least 1 dose of study medication.

Arm	Measure	Value (LEAST_SQUARES_MEAN)	Dispersion
Glycopyrronium Bromide 50 μg	Percentage of Nights With no Nighttime Awakenings During the Study (Baseline to Week 52)	57.36 Percentage of nights	Standard Error 1.842
Placebo to Glycopyrronium Bromide	Percentage of Nights With no Nighttime Awakenings During the Study (Baseline to Week 52)	52.15 Percentage of nights	Standard Error 2.239
Tiotropium 18 μg	Percentage of Nights With no Nighttime Awakenings During the Study (Baseline to Week 52)	55.47 Percentage of nights	Standard Error 2.23

Secondary

Percentage of Patients Who Experienced a Moderate or Severe Chronic Obstructive Pulmonary Disease (COPD) Exacerbation During the Study (Baseline to Week 52)

A COPD exacerbation was considered to be moderate if treatment with systemic corticosteroids and/or antibiotic was required. A COPD exacerbation was considered to be severe if treatment for moderate severity and hospitalization was required.

Time frame: Baseline to Week 52

Population: Full Analysis Set (FAS): All randomized patients who received at least 1 dose of study medication.

Arm	Measure	Value (NUMBER)
Glycopyrronium Bromide 50 μg	Percentage of Patients Who Experienced a Moderate or Severe Chronic Obstructive Pulmonary Disease (COPD) Exacerbation During the Study (Baseline to Week 52)	32.8 Percentage of participants
Placebo to Glycopyrronium Bromide	Percentage of Patients Who Experienced a Moderate or Severe Chronic Obstructive Pulmonary Disease (COPD) Exacerbation During the Study (Baseline to Week 52)	40.2 Percentage of participants
Tiotropium 18 μg	Percentage of Patients Who Experienced a Moderate or Severe Chronic Obstructive Pulmonary Disease (COPD) Exacerbation During the Study (Baseline to Week 52)	30.1 Percentage of participants

Secondary

Time to First Moderate or Severe Chronic Obstructive Pulmonary Disease (COPD) Exacerbation During the Study (Baseline to Week 52)

Time to first moderate or severe COPD exacerbation was calculated as the number of days from baseline to the day on which the patient experienced the first moderate or severe COPD exacerbation. A COPD exacerbation was considered to be moderate if treatment with systemic corticosteroids and/or antibiotic was required. A COPD exacerbation was considered to be severe if treatment for moderate severity and hospitalization was required.

Time frame: Baseline to Week 52 (patients with no moderate or severe exacerbations who completed the study were censored at the final visit date, which may have exceeded 52 weeks)

Population: Full Analysis Set (FAS): All randomized patients who received at least 1 dose of study medication.

Arm	Measure	Value (MEDIAN)
Glycopyrronium Bromide 50 μg	Time to First Moderate or Severe Chronic Obstructive Pulmonary Disease (COPD) Exacerbation During the Study (Baseline to Week 52)	363.0 Days
Placebo to Glycopyrronium Bromide	Time to First Moderate or Severe Chronic Obstructive Pulmonary Disease (COPD) Exacerbation During the Study (Baseline to Week 52)	231.0 Days
Tiotropium 18 μg	Time to First Moderate or Severe Chronic Obstructive Pulmonary Disease (COPD) Exacerbation During the Study (Baseline to Week 52)	364.0 Days

Secondary

Transition Dyspnea Index (TDI) at Week 26

The TDI measured changes in dyspnea from baseline during treatment and included 3 domains: Functional impairment (activities of daily living), magnitude of task (intensity of activity), and magnitude of effort (difficulty breathing). Each domain was rated from -3 to 3 (major deterioration-major improvement). The total score ranged from -9 to 9; minus scores indicate deterioration. The analysis included the same covariates as the primary Outcome Measure.

Time frame: Week 26

Population: Full Analysis Set (FAS): All randomized patients who received at least 1 dose of study medication.

Arm	Measure	Value (LEAST_SQUARES_MEAN)	Dispersion
Glycopyrronium Bromide 50 μg	Transition Dyspnea Index (TDI) at Week 26	2.13 Units on a scale	Standard Error 0.24
Placebo to Glycopyrronium Bromide	Transition Dyspnea Index (TDI) at Week 26	1.32 Units on a scale	Standard Error 0.289
Tiotropium 18 μg	Transition Dyspnea Index (TDI) at Week 26	2.26 Units on a scale	Standard Error 0.281

Secondary

Trough Forced Expiratory Volume in 1 Second (FEV1) at Day 1, Week 26, and Week 52

Time frame: Day 1, Week 26, and Week 52

Population: Full Analysis Set (FAS): All randomized patients who received at least 1 dose of study medication.

Arm	Measure	Group	Value (LEAST_SQUARES_MEAN)	Dispersion
Glycopyrronium Bromide 50 μg	Trough Forced Expiratory Volume in 1 Second (FEV1) at Day 1, Week 26, and Week 52	Week 52 (n=416, 196, 210)	1.412 Liters	Standard Error 0.0157
Glycopyrronium Bromide 50 μg	Trough Forced Expiratory Volume in 1 Second (FEV1) at Day 1, Week 26, and Week 52	Week 26 (n=451, 219, 233)	1.458 Liters	Standard Error 0.0161
Glycopyrronium Bromide 50 μg	Trough Forced Expiratory Volume in 1 Second (FEV1) at Day 1, Week 26, and Week 52	Day 1	1.478 Liters	Standard Error 0.0088
Placebo to Glycopyrronium Bromide	Trough Forced Expiratory Volume in 1 Second (FEV1) at Day 1, Week 26, and Week 52	Week 52 (n=416, 196, 210)	1.303 Liters	Standard Error 0.0198
Placebo to Glycopyrronium Bromide	Trough Forced Expiratory Volume in 1 Second (FEV1) at Day 1, Week 26, and Week 52	Week 26 (n=451, 219, 233)	1.324 Liters	Standard Error 0.0196
Placebo to Glycopyrronium Bromide	Trough Forced Expiratory Volume in 1 Second (FEV1) at Day 1, Week 26, and Week 52	Day 1	1.388 Liters	Standard Error 0.0109
Tiotropium 18 μg	Trough Forced Expiratory Volume in 1 Second (FEV1) at Day 1, Week 26, and Week 52	Week 26 (n=451, 219, 233)	1.408 Liters	Standard Error 0.0191
Tiotropium 18 μg	Trough Forced Expiratory Volume in 1 Second (FEV1) at Day 1, Week 26, and Week 52	Day 1	1.471 Liters	Standard Error 0.0109
Tiotropium 18 μg	Trough Forced Expiratory Volume in 1 Second (FEV1) at Day 1, Week 26, and Week 52	Week 52 (n=416, 196, 210)	1.392 Liters	Standard Error 0.0191

Secondary

Trough Forced Vital Capacity (FVC) at Day 1, Week 12, Week 26, and Week 52

Trough FVC is defined as the average of the post-dose 23 h 15 min and the 23 h 45 min FVC values. Just prior to FVC measurement, patients performed normal tidal breathing. The patient was given a few breaths warning before being told At the end of the next normal breath out, take a deep breath all the way in; they were then verbally encouraged to make a maximal effort before relaxing. The analysis included the same covariates as the primary Outcome Measure.

Time frame: Day 1, Week 12, Week 26, and Week 52

Population: Full Analysis Set (FAS): All randomized patients who received at least 1 dose of study medication.

Arm	Measure	Group	Value (LEAST_SQUARES_MEAN)	Dispersion
Glycopyrronium Bromide 50 μg	Trough Forced Vital Capacity (FVC) at Day 1, Week 12, Week 26, and Week 52	Day 1	2.936 Liters	Standard Error 0.0165
Glycopyrronium Bromide 50 μg	Trough Forced Vital Capacity (FVC) at Day 1, Week 12, Week 26, and Week 52	Week 12 (n=442, 204, 217)	2.985 Liters	Standard Error 0.0265
Glycopyrronium Bromide 50 μg	Trough Forced Vital Capacity (FVC) at Day 1, Week 12, Week 26, and Week 52	Week 52 (n=395, 186, 201)	2.866 Liters	Standard Error 0.0335
Glycopyrronium Bromide 50 μg	Trough Forced Vital Capacity (FVC) at Day 1, Week 12, Week 26, and Week 52	Week 26 (n=418, 196, 208)	2.962 Liters	Standard Error 0.0299
Placebo to Glycopyrronium Bromide	Trough Forced Vital Capacity (FVC) at Day 1, Week 12, Week 26, and Week 52	Week 12 (n=442, 204, 217)	2.802 Liters	Standard Error 0.0329
Placebo to Glycopyrronium Bromide	Trough Forced Vital Capacity (FVC) at Day 1, Week 12, Week 26, and Week 52	Week 26 (n=418, 196, 208)	2.758 Liters	Standard Error 0.0361
Placebo to Glycopyrronium Bromide	Trough Forced Vital Capacity (FVC) at Day 1, Week 12, Week 26, and Week 52	Day 1	2.757 Liters	Standard Error 0.0205
Placebo to Glycopyrronium Bromide	Trough Forced Vital Capacity (FVC) at Day 1, Week 12, Week 26, and Week 52	Week 52 (n=395, 186, 201)	2.687 Liters	Standard Error 0.0399
Tiotropium 18 μg	Trough Forced Vital Capacity (FVC) at Day 1, Week 12, Week 26, and Week 52	Week 52 (n=395, 186, 201)	2.866 Liters	Standard Error 0.0383
Tiotropium 18 μg	Trough Forced Vital Capacity (FVC) at Day 1, Week 12, Week 26, and Week 52	Week 12 (n=442, 204, 217)	2.970 Liters	Standard Error 0.0323
Tiotropium 18 μg	Trough Forced Vital Capacity (FVC) at Day 1, Week 12, Week 26, and Week 52	Day 1	2.930 Liters	Standard Error 0.0206
Tiotropium 18 μg	Trough Forced Vital Capacity (FVC) at Day 1, Week 12, Week 26, and Week 52	Week 26 (n=418, 196, 208)	2.892 Liters	Standard Error 0.0355

Source: ClinicalTrials.gov · Data processed: Mar 10, 2026

1-year Study to Assess the Efficacy, Safety, and Tolerability of Glycopyrronium Bromide (NVA237) in Chronic Obstructive Pulmonary Disease (COPD)

Conditions

Keywords

Brief summary

Related papers

Interventions

Sponsors

Study design

Eligibility

Inclusion criteria

Exclusion criteria

Design outcomes

Primary

Secondary

Countries

Participant flow

Recruitment details

Participants by arm

Withdrawals & dropouts

Baseline characteristics

Adverse events

Outcome results

Trough Forced Expiratory Volume in 1 Second (FEV1) at Week 12

Change From Baseline in the Mean Daily Number of Puffs of Rescue Medication Taken During the Study (Baseline to Week 52)

Change From Baseline in the Mean Daily Total Symptom Score During the Study (Baseline to Week 52)

Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52

Forced Expiratory Volume in 1 Second (FEV1) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post Dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52

Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 12 Hours Post-dose at Day 1 and Weeks 12 and 52

Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 23 Hours 45 Minutes and From 12 Hours to 23 Hours 45 Minutes Post-dose at Weeks 12 and 52

Forced Expiratory Volume in 1 Second (FEV1) Standardized (With Respect to Length of Time) Area Under the Curve (AUC) From 5 Minutes to 4 Hours Post-dose at Day 1 and Weeks 12, 26, and 52

Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; 1, 2, 3, 4, 6, 8, 10, and 12 Hours; 23 Hours 15 Minutes; and 23 Hours 45 Minutes Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52

Forced Vital Capacity (FVC) 5, 15, and 30 Minutes; and 1, 2, 3, and 4 Hours Post-dose at Days 1 and 15; and Weeks 5, 9, 12, 16, 20, 26, 34, 42, 50, and 52

Health-related Quality of Life (QoL) Assessed With the St. George Respiratory Questionnaire (SGRQ) at Week 52

Number of Moderate or Severe Exacerbations of Chronic Obstructive Pulmonary Disease (COPD) Per Year During the Study (Baseline to Week 52)

Percentage of Days Able to Perform Usual Daily Activities During the Study (Baseline to Week 52)

Percentage of Days With no Daytime Symptoms During the Study (Baseline to Week 52)

Percentage of Nights With no Nighttime Awakenings During the Study (Baseline to Week 52)

Percentage of Patients Who Experienced a Moderate or Severe Chronic Obstructive Pulmonary Disease (COPD) Exacerbation During the Study (Baseline to Week 52)

Time to First Moderate or Severe Chronic Obstructive Pulmonary Disease (COPD) Exacerbation During the Study (Baseline to Week 52)

Transition Dyspnea Index (TDI) at Week 26

Trough Forced Expiratory Volume in 1 Second (FEV1) at Day 1, Week 26, and Week 52

Trough Forced Vital Capacity (FVC) at Day 1, Week 12, Week 26, and Week 52