Mindfulness Based Cognitive Therapy and Antidepressant Medication in Recurrent Depression

Conditions

Depressive Disorder, Major

Keywords

Recurrent Major Depressive Disorder, Mindfulness Based Cognitive Therapy, Cost-effectiveness, Antidepressant medication, Randomized Controlled Trial

Brief summary

The purpose of this study is to investigate the (cost)effectiveness of mindfulness based cognitive therapy (MBCT) compared to that of antidepressant medication, and its combination with regard to the prevention of relapse or recurrence in patients with recurrent depression.

Detailed description

In the Netherlands, treatment as usual for patients with (recurrent) Major Depressive Disorder consists of maintenance antidepressant medication. Mindfulness-based cognitive therapy (MBCT) is a recently developed psychological intervention that appears to be promising in terms of preventing relapse or recurrence in patients with recurrent depression. It consists of 8 weekly group sessions in which meditation exercises are combined with cognitive therapeutic elements such as identifying negative thoughts and monitoring and scheduling activities. In this study, the (cost)effectiveness of a) MBCT on its own, b) antidepressant medication on its own and c) the combination of MBCT and antidepressant medication will be investigated in 350 patients with recurrent depression who are currently in remission.

Marloes J. Huijbers, Carolien Wentink, Esther M.F. Simons, Jan Spijker, Anne E.M. Speckens

BMJ Open2020-11-0116 citations

10.1136/bmjopen-2020-039053

Discontinuation of antidepressant medication after mindfulness-based cognitive therapy for recurrent depression: randomised controlled non-inferiority trial.

Huijbers MJ, Spinhoven P, Spijker J, Ruhé HG, van Schaik DJ, van Oppen P, Nolen WA, Ormel J, Kuyken W, van der Wilt GJ, Blom MB, Schene AH, Rogier A, Donders T, Speckens AE.

2016-02-1838 citations

10.1192/bjp.bp.115.168971

Preventing relapse in recurrent depression using mindfulness-based cognitive therapy, antidepressant medication or the combination: trial design and protocol of the MOMENT study.

Huijbers MJ, Spijker J, Donders AR, van Schaik DJ, van Oppen P, Ruhé HG, Blom MB, Nolen WA, Ormel J, van der Wilt GJ, Kuyken W, Spinhoven P, Speckens AE.

2012-08-2729 citations

10.1186/1471-244x-12-125

Interventions

BEHAVIORALMindfulness Based Cognitive Therapy

Mindfulness Based Cognitive Therapy is an 8-week during group intervention encompassing meditation practice and cognitive therapy techniques.

DRUGOptimal Medical Care

Therapeutic dose of antidepressant medication

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Recurrent Major Depressive Episode (at least 3 previous episodes) * Treatment with therapeutic dose of antidepressant medication during past six months * Currently in full or partial remission

Exclusion criteria

* Bipolar disorder (current and previous (hypo)manic episodes) * Psychotic disorder (current and previous) * Neurological or somatic illness affecting depression or outcome measures * Current alcohol or drugs dependency * Use of high dosage benzodiazepines (\> 2 mg Lorazepam equivalents daily) * Recent Electro Convulsive Therapy (\< 3 months ago)

Design outcomes

Primary

Measure	Time frame	Description
Relapse/recurrence of Major Depressive Episode	3, 6, 9, 12, 15 months	Relapse or recurrence of depression will be assessed trimonthly using the Structured Clinical Interview for DSM-V (SCID) depression module.

Secondary

Measure	Time frame	Description
Costs made by consumption of medical care and production loss	3, 6, 9, 12, 15 months	Using prospective calendars and retrospective questionnaires about contacts with health care in the past 3 months (assessed trimonthly) we will estimate the costs of depression health care and the quality of life (selfreport). We will compare the cost-effectiveness ratios between the groups.

Countries

Netherlands

Outcome results

None listed