Effects of Oxybutynin Topical Gel on Gastric Emptying

Effect of Oxybutynin Chloride Topical Gel on Gastric Emptying, Using the Acetaminophen Absorption Test

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00926926

Enrollment

Registered

2009-06-24

Start date

2009-06-30

Completion date

2009-07-31

Last updated

2012-10-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Healthy volunteer

Brief summary

This study explores the effect of oxybutynin topical gel on gastric emptying

Interventions

DRUGOxybutynin Chloride Gel

Once daily for 7 days, followed by single dose of acetaminophen

DRUGPlacebo Gel

Once daily for 7 days, followed by single dose of acetaminophen

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Adult, healthy, post-menopausal females

Exclusion criteria

* Patients for whom OTG or acetaminophen is contraindicated. * Abnormality of the GI tract. * Taking drugs that affect gastric motility.

Design outcomes

Primary

Measure	Time frame
The effect of oxybutynin chloride topical gel administration on gastric emptying will be assessed by comparing the single dose relative bioavailability of acetaminophen	After 7 days of treatment

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026