Posterior Macular Adhesion: A Potential Risk Factor for Non-exudative Age Related Macular Degeneration (AMD) to Develop Exudative AMD

Posterior Macular Adhesion: A Potential Risk Factor for Non-exudative AMD to Develop Exudative AMD

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00926861

Acronym

PAM

Enrollment

320

Registered

2009-06-24

Start date

2009-07-31

Completion date

2012-12-31

Last updated

2010-06-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Detachment of the Posterior Hyaloid, Dry Age-related Macular Degeneration

Keywords

age-related macular degeneration, detachment of the posterior hyaloid, AMD

Brief summary

Choroidal neovascularisation in age related macular degeneration is one of the major causes of legal blindness in the western world existing in two major occurences, the dry and the wet form.The etiology of age related macular degeneration is yet unknown. Genetic factors, oxidative stress, Ischaemia, and aging of the retinal pigment epithelium are discussed as etiologic factors. The risk of rapid vision loss is much higher in wet AMD, a dry form may transform to a wet form. From a prior study the investigators know that the posterior hyaloid is significantly more frequent attached in wet AMD. This study is conducted to examine whether the attached posterior hyaloid is a risk factor to develop wet AMD in dry AMD cases.

Interventions

DEVICEultrasound

A-scan and B-scan ultrasound at baseline and month 6,12,24

DEVICEOCT

Volume scans of spectralis OCT at baseline and month 6,12,24

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Healthy volunteers

Inclusion criteria

* Dry MD * Age over 50 years

Exclusion criteria

* Macular pathologies other than age related macular degeneration (like diabetic maculopathy, macular pucker, macular hole) * Prior vitrectomy or buckle surgery * Uveitis posterior, multifocal chorioiditis * Pathologic myopia * Diabetic retinopathy * Visualization of the macula not possible (dens cataract, vitreous haemorrhage)

Design outcomes

Primary

Measure	Time frame
Number of eyes with non-exudative AMD with attached and detached posterior vitreous cortex developing exudative AMD	24 months

Secondary

Measure	Time frame
Distance acuity	24 months
Age	24 months
Smoking	24 months
Obesity	24 months
Lesion classification (AREDS)	24 months

Countries

Austria

Contacts

Primary ContactIlse Krebs, MD

ilse.krebs@wienkav.at+43171165

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026