Healthy
Conditions
Keywords
B-cells, CD5+, B1 Cells, Healthy Controls
Brief summary
The aim of this research is to define the human equivalent of mouse B1 cells.
Detailed description
The specific aim of this research project is to define the human equivalent of mouse B1 cells. This will be done by evaluating IgM secretion, surface markers, functional characteristics, V gene usage, N-region addition, and phosphorylation status of intracellular proteins, gene expression, sequencing of immunoglobulin genes, determination of antigenic specificity, replication history, and response to different stimuli. The goal of this project is to begin to the translation of decades of basic science research and research in the mouse model into the human system. It is believed that properly defining this B cell subset in humans will lead to better therapeutics, prognostics and prevention for a number of disease including infections, autoimmune disease, and cancer.
Interventions
OTHERBlood draw
Subject will have blood draw.
Sponsors
Northwell Health
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Subject is considered by the physician to be a healthy adult.
Exclusion criteria
* Subject is under the age of 18 * Subject has an infection or is currently ill
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Presence of B-1 cells in humans | determined over the years study in effect | an equivalent cell type was isolated in humans |
Countries
United States
Outcome results
None listed