Interstitial Lung Disease, Pulmonary Arterial Hypertension, Pulmonary Hypertension
Conditions
Keywords
Pulmonary Hypertension, Pulmonary Arterial Hypertension, Interstitial Lung Disease, MIF
Brief summary
We hypothesize that hypoxia-induced pulmonary vascular remodeling is mediated by macrophage migration inhibitory factor (MIF), that remodeling is in fact the reflection of a chronic inflammatory process, and that MIF may be a useful biomarker of the severity and progression of both ILD and PH.
Detailed description
We hypothesize that hypoxia-induced pulmonary vascular remodeling is mediated by macrophage migration inhibitory factor (MIF), that remodeling is in fact the reflection of a chronic inflammatory process, and that MIF may be a useful biomarker of the severity and progression of both ILD and PH. To study this hypothesis, we have two specific aims: 1. To evaluate plasma MIF concentration as a marker of severity in ILD and PH and 2. To determine the utility of breathe condensate analysis in the evaluation of ILD and PH. If we are successful in identifying MIF as a biomarker, it may identify MIF as a useful therapeutic target, as we have shown in other inflammatory disorders.
Interventions
OTHERBlood Gas
Subject will have both venous and arterial blood draws to assess for the bloods content of MIF
OTHERPulmonary Exercise Test
Subject will ride exercise bike to assess their pulmonary function level.
OTHERSpirometry
To assess subjects lung function
OTHERBreath Condensate Collector
Subject with use breathing apparatus to allow researchers to collect breath condensate to assess level of MIF in breathe condensate.
Sponsors
Northwell Health
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Subject are at least 18 years of age * Subject has confirmed Pulmonary Hypertension and Interstitial Lung Disease * Subject are able to complete study procedures, such as spirometry, and Pulmonary Exercise test.
Exclusion criteria
* Subject are pregnant * Subject is unable to perform tasks associated with study
Countries
United States
Outcome results
None listed