Screening Intracranial Aneurysms With Magnetic Resonance Angiography (MRA) in China

Epidemiology of Cerebral Aneurysms With MRA in China in Middle-aged or Elder Person: a Population-based Survey

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00926172

Enrollment

4500

Registered

2009-06-23

Start date

2007-06-30

Completion date

2010-06-30

Last updated

2009-12-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intracranial Aneurysm

Keywords

Magnetic resonance angiography, Intracranial aneurysm, cerebral aneurysm, unruptured aneurysm, Epidemiology, Magnetic Resonance Imaging

Brief summary

The Chinese Cerebral Aneurysms Survey is a continuing prospective study among middle-aged and older individuals (35 - 75 years) that aims to determine the prevalence of cerebral intracranial aneurysms in the general population with MRA at 3.0 Tesla (T).

Detailed description

Cerebral intracranial aneurysms are common. In angiographic and autopsy studies, estimates for prevalence vary between 0.2 and 9.9 percent. The methods used to detect the aneurysms markedly influenced the proportion of aneurysms. Retrospective autopsy studies probably give an underestimation and prospective angiography studies an overestimation of the actual prevalence. Accurate data on the prevalence of intracranial aneurysms are essential in evaluating the results of screening programs for aneurysms in general population. During the past decade, MRA, as a preferred accuracy modality for noninvasive intracranial vascular imaging at most centers, is playing an increasing role in the evaluation of patients suspected of having intracranial aneurysms. In recurrent study, we have tested that MRA at 3T has excellent sensitivity, accuracy, and correlation with DSA and is comparable to catheter cerebral angiography for the evaluation of patients with intracranial aneurysms (Stroke, in press). Therefore, we examined trends in intracranial aneurysm prevalence with the use of MRA at 3.0T to determine the true prevalence of cerebral intracranial aneurysms in the general middle-aged or elder population.

Interventions

None listed

Study design

Observational model

ECOLOGIC_OR_COMMUNITY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

35 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Native inhabitants lived in a defined area sites in China * Aged 35-75 years

Exclusion criteria

* Less than 35 years old or more than 75 years old * Incompetent patient who cannot give consent for routine MR Angiography and his/her surrogate decision maker is not available * Any patients with a contraindication to having a standard MRI examination, such as phase maker, orbital metallic foreign body, etc.

Design outcomes

Primary

Measure	Time frame
Cerebral intracranial aneurysms identified by 3-D TOF-MRA at 3T	18 months after the study

Secondary

Measure	Time frame
Suspected cerebral aneurysms detected by MRA underwent digital subtraction angiography (DSA) examination	32-36 months

Countries

China

Contacts

Primary ContactYong-Dong Li, MD, PhD

dr_liyongdong@sina.com.cn0086-21-64844183

Backup ContactMing-Hua Li, MD, PhD

liminhua@online.sh.cn0086-21-64844183

Outcome results