Acute Respiratory Failure
Conditions
Brief summary
The study is aimed to assess the possible benefit of non-positive pressure mechanical support in front of conventional ventilation in patients admitted to the intensive care unit (ICU) because of pure hypoxemic respiratory failure.
Detailed description
Pure hypoxemic patients admitted to intensive care unit in a teaching hospital have been randomized to be treated by conventional ventilatory support or non-positive mechanical ventilation support. Those patients who did not benefit from the experimental non-positive ventilatory support, were intubated and conventionally mechanically ventilated and discarded for analysis. The primary outcome was mortality rate in both groups, and secondary outcomes were length of stay, improvement of oxygenation, and reduced complications rates.
Interventions
PROCEDUREnon positive pressure mechanical ventilatory support
Sponsors
Hospital Provincial de Castellon
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* dyspnea with respiratory rates higher than 35 p.m. * pO2 \< 65 mmHg * paO2/FiO2 \< 250
Exclusion criteria
* respiratory or cardiac arrest * gastrointestinal bleeding * hemodynamic instability * face surgery * upper airway obstruction * inability for active cooperation * need for airway protection * exacerbation of COPD * decrease of conscious level * acute pulmonary cardiogenic oedema
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mortality rates | patient hospital discharge |
Secondary
| Measure | Time frame |
|---|---|
| oxygenation improve | patient hospital discharge |
| diminishing of tracheal intubation incidence | patient hospital discharge |
| ICU and Post ICU hospital length of stay | patient hospital discharge |
Countries
Spain
Outcome results
None listed