Neurosurgery
Conditions
Keywords
vancomycin, teicoplanin, linezolid, intravenous, cerebrospinal fluid, CSF, pharmacokinetics, penetration, blood-brain barrier, Pharmacokinetics of three antibiotics in relation to cerebrospinal fluid
Brief summary
Three different antibiotics are used to prevent infection in case of neurosurgery - this study examines to which extent the antibiotics penetrate from the blood to the cerebrospinal fluid (surrounding the brain).
Interventions
DRUGVancomycin
Vancomycin is administered intravenously and subsequently measured in cerebrospinal fluid sample
DRUGTeicoplanin
Teicoplanin is administered intravenously and subsequently measured in cerebrospinal fluid sample
DRUGLinezolid
Linezolid is administered intravenously and subsequently measured in cerebrospinal fluid sample
Sponsors
Aarhus University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Over 18 years old * Already having an external CSF drain * Scheduled for neurosurgery requiring antibiotic prophylaxis (most commonly placement of an internal drain (shunt)
Exclusion criteria
* Infection or colonization requiring other than standard prophylactic antibiotics
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of antibiotics in cerebrospinal fluid | 1, 2, 4, 6, 12 hours | Concentration in CSF past i.v. injection |
Outcome results
None listed